期刊
CLINICAL AND TRANSLATIONAL ALLERGY
卷 10, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13601-020-00319-w
关键词
Allergen; BAMSE; Birth cohort; Immunoglobulin E; Prevalence; Sensitization
类别
资金
- European Research Council (TRIBAL) [757919]
- Swedish Research Council
- Swedish Heart-Lung Foundation
- Region Stockholm (ALF project)
- Ake Wiberg foundation
- Swedish Asthma and Allergy Research Foundation
- Cancer and Allergy Foundation
- Karolinska Institute
- European Research Council (ERC) [757919] Funding Source: European Research Council (ERC)
Background Up to half of the population in high-income countries has allergen-specific IgE antibodies. However, data regarding sex differences of IgE-sensitization from childhood to adulthood is limited. Objective To explore IgE-sensitization to common foods and airborne allergens in relation to sex over time in a population-based cohort followed up to young adulthood. Methods The Swedish population-based birth cohort BAMSE includes 4089 subjects who have been followed regularly with questionnaires and clinical investigations. A recent 24-year follow-up included 3069 participants (75%). Sera collected at 4, 8, 16 and 24 years were analyzed for IgE-antibodies to 14 common foods and airborne allergens. Results At 24 years sensitization to foods had decreased compared to previous follow-ups affecting 8.4%, while sensitization to airborne allergens was more common, affecting 42.2%. Male sex was associated with IgE-sensitization to airborne allergens at all ages (overall OR: 1.68, 95% CI 1.46-1.94) while there was no statistically significant association between sex and sensitization to food allergens (overall OR: 1.10, 95% CI 0.93-1.32). Levels of allergen-specific IgE did not differ significantly between males and females for any of the tested foods or airborne allergens at any age, following adjustment for multiple comparisons. Conclusion IgE-sensitization to airborne allergens increases with age up to young adulthood, whereas sensitization to food allergens seems to level off. Male sex is strongly associated with IgE-sensitization to airborne allergens from early childhood up to young adulthood. In contrast, there is little evidence for associations between sex and IgE-sensitization to foods.
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