期刊
FRONTIERS IN ENDOCRINOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2020.00149
关键词
BMI; cumulative live birth rate; in vitro fertilization; overweight; underweight
资金
- General Project of Science and Technology Department of Shaanxi Province -Social Development Field [2018SF-260]
- Special Research Fund of Clinical Medicine of Chinese Medical Association -Research and Development Project of Young Doctors in Reproductive Medicine [17020120681]
- National Natural Science Funding of China [81673224]
- Natural Science Funding of Shaanxi Province [2019JM029]
Objective: To investigate the cumulative live birth rates (CLBR) according to body mass index (BMI) in women undergoing their first in vitro fertilization (IVF). Design: Retrospective cohort analysis. Setting: An IVF clinic in a public hospital. Patients: This is a retrospective study of 14,782 patients undergoing their first fresh IVF cycles and subsequent frozen embryo transfers in our clinic from January 2014 to January 2017. The follow-up for CLBR continued until January 2019. Patients with a BMI 24 kg/m(2) were considered to be overweight. Patients with a BMI >= 28 kg/m(2) were considered to be obese. Intervention(s): None. Primary Outcome Measure: The primary outcome was cumulative live birth rate (CLBR). Result(s): This study illustrated the inverted U shape associations between body weight and IVF outcome (CLBR). The turning points in threshold analysis, as found by an automatic search, were BMIs of 18.5 and 30.4 kg/m(2). The main finding of this retrospective data analysis is that the CLBR increased in underweight women, plateaued for normal weight and overweight women with a BMI between 18.5 and 30.4 kg/m(2), and decreased in obese women. Conclusion(s): The data suggested an inverted U shape association between BMI and CLBR. The CLBR increases in underweight women, plateaus in normal weight and overweight women, and then decreases in obese women.
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