期刊
FRONTIERS IN CHEMISTRY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2020.00249
关键词
phosphate-based glasses; strontium-doped; tissue engineering; bioresorbable glasses; sol-gel
资金
- EPSRC [EP/P033636/1]
- Royal Society [RSG\R1\180191]
- EPSRC [EP/P033636/1, 1976273] Funding Source: UKRI
Mesoporous phosphate-based glasses have great potential as biomedical materials being able to simultaneously induce tissue regeneration and controlled release of therapeutic molecules. In the present study, a series of mesoporous phosphate-based glasses in the P2O5-CaO-Na2O system, doped with 1, 3, and 5 mol% of Sr2+, were prepared using the sol-gel method combined with supramolecular templating. A sample without strontium addition was prepared for comparison. The non-ionic triblock copolymer EO20PO70EO20 (P123) was used as a templating agent. Scanning electron microscopy (SEM) images revealed that all synthesized glasses have an extended porous structure. This was confirmed by N-2 adsorption-desorption analysis at 77 K that shows a porosity typical of mesoporous materials. P-31 magic angle spinning nuclear magnetic resonance (P-31 MAS-NMR) and Fourier transform infrared (FTIR) spectroscopies have shown that the glasses are mainly formed by Q(1) and Q(2) phosphate groups. Degradation of the glasses in deionized water assessed over a 7-day period shows that phosphate, Ca2+, Na+, and Sr2+ ions can be released in a controlled manner over time. In particular, a direct correlation between strontium content and degradation rate was observed. This study shows that Sr-doped mesoporous phosphate-based glasses have great potential in bone tissue regeneration as materials for controlled delivery of therapeutic ions.
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