期刊
ACS CENTRAL SCIENCE
卷 6, 期 5, 页码 622-635出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscentsci.9b00916
关键词
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资金
- National Natural Science Foundation of China [21625201, 21961142010, 21661140001, 91853202, 21521003]
- National Key Research and Development Program of China [2017YFA0505200]
- Beijing Outstanding Young Scientist Program [BJJWZYJH01201910001001]
Late-stage diversification of natural products is an efficient way to generate natural product derivatives for drug discovery and chemical biology. Benefiting from the development of site-selective synthetic methodologies, late-stage diversification of natural products has achieved notable success. This outlook will outline selected examples of novel methodologies for site-selective transformations of reactive functional groups and inert C-H bonds that enable late-stage diversification of complex natural products. Accordingly, late-stage diversification provides an opportunity to rapidly access various derivatives for modifying lead compounds, identifying cellular targets, probing protein-protein interactions, and elucidating natural product biosynthetic relationships.
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