期刊
TRANSLATIONAL CANCER RESEARCH
卷 9, 期 3, 页码 2012-2025出版社
AME PUBL CO
DOI: 10.21037/tcr.2020.01.17
关键词
Circulating tumor cells (CTCs); circulating tumor cell enrichment (CTC enrichment); magnetic bead separation; microfluidics; liquid biopsy
类别
资金
- Scientific Research Project of Jiading Health and Family Planning Commission [2018-QN-13]
- Shanghai Science and Technology Development Funds [19QB1405900]
Circulating tumor cells (CTCs) are cells derived from the primary sites of tumor patients into peripheral blood and serve as seeds that initiate tumor metastasis to distant sites. As a primary form of liquid biopsy, CTC enumeration has exhibited great potential as a mean to obtain diagnostic and prognostic biomarker information in various cancers. The comprehensive clinical utility of CTC tests, however, is still restricted due to the scarcity and heterogeneity of CTCs, which necessitates reliable techniques for their efficient enrichment and characterization. Numerous methods have been developed to improve yield and purity of CTC enrichment as well as detection sensitivity. In this review, we comprehensively summarize techniques for CTC enrichment and detection.
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