期刊
REDOX BIOLOGY
卷 32, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.redox.2020.101511
关键词
Ataxia; Mitochondria; Reactive oxygen species; DNA repair
资金
- Howard Hughes Medical Institute
The Ataxia-telangiectasia mutated (ATM) kinase responds to DNA double-strand breaks and other forms of cellular stress, including reactive oxygen species (ROS). Recent work in the field has uncovered links between mitochondrial ROS and ATM activation, suggesting that ATM acts as a sensor for mitochondrial derived ROS and regulates ROS accumulation in cells through this pathway. In addition, characterization of cells from Ataxia-telangiectasia patients as well as ATM-deficient mice and cell models suggest a role for ATM in modulating mitochondrial gene expression and function. Here we review ROS responses related to ATM function, recent evidence for ATM roles in mitochondrial maintenance and turnover, and the relationship between ATM and regulation of protein homeostasis.
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