期刊
REDOX BIOLOGY
卷 34, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.redox.2020.101475
关键词
NRF2; Heavy metals; Pesticides; Air pollutants; Epigenetic modi fications; Redox signaling pathways
资金
- National Institutes of Health [R01ES07331, R01ES10563]
- National Natural Science Foundation of China [81573195, 81903352, 81973083]
- Joint Funds for the Innovation of Science and Technology, Fujian province [2017Y9105]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [18H05293, 17K15489]
- Grants-in-Aid for Scientific Research [17K15489] Funding Source: KAKEN
Living organisms are surrounded with heavy metals such as methylmercury, manganese, cobalt, cadmium, ar-senic, as well as pesticides such as deltamethrin and paraquat, or atmospheric pollutants such as quinone. Extensive studies have demonstrated a strong link between environmental pollutants and human health. Redox toxicity is proposed as one of the main mechanisms of chemical-induced pathology in humans. Acting as both a sensor of oxidative stress and a positive regulator of antioxidants, the nuclear factor erythroid 2-related factor 2 (NRF2) has attracted recent attention. However, the role NRF2 plays in environmental pollutant-induced toxicity has not been systematically addressed. Here, we characterize NRF2 function in response to various pollutants, such as metals, pesticides and atmospheric quinones. NRF2 related signaling pathways and epigenetic regula-tions are also reviewed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据