期刊
NATIONAL SCIENCE REVIEW
卷 7, 期 6, 页码 1003-1011出版社
OXFORD UNIV PRESS
DOI: 10.1093/nsr/nwaa037
关键词
2019-nCoV; COVID-19; cytokine storm; IP-10; IL-17
资金
- National Natural Science Foundation of China [81788101]
- Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences [2017-12M-1-009]
- Ministry of Science and Technology [2020YFC0846300]
- National Science and Technology Major Project [2018ZX10711001]
- Shenzhen Science and Technology Research and Development Project [202002073000001]
A recent outbreak of pneumonia in Wuhan, China was found to be caused by a 2019 novel coronavirus (2019-nCoV or SARS-CoV-2 or HCoV-19). We previously reported the clinical features of 12 patients with 2019-nCoV infections in Shenzhen, China. To further understand the pathogenesis of COVID-19 and find better ways to monitor and treat the disease caused by 2019-nCoV, we measured the levels of 48 cytokines in the blood plasma of those 12 COVID-19 patients. Thirty-eight out of the 48 measured cytokines in the plasma of 2019-nCoV-infected patients were significantly elevated compared to healthy individuals. Seventeen cytokines were linked to 2019-nCoV loads. Fifteen cytokines, namely M-CSF, IL-10, IFN-alpha 2, IL-17, IL-4, IP-10, IL-7, IL-1ra, G-CSF, IL-12, IFN-gamma, IL-1 alpha, IL-2, HGF and PDGF-BB, were strongly associated with the lung-injury Murray score and could be used to predict the disease severity of 2019-nCoV infections by calculating the area under the curve of the receiver-operating characteristics. Our results suggest that 2019-nCoV infections trigger extensive changes in a wide array of cytokines, some of which could be potential biomarkers of disease severity of 2019-nCoV infections. These findings will likely improve our understanding of the immunopathologic mechanisms of this emerging disease. Our results also suggest that modulators of cytokine responses may play a therapeutic role in combating the disease once the functions of these elevated cytokines have been characterized.
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