期刊
MYCOBIOLOGY
卷 48, 期 2, 页码 148-152出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/12298093.2020.1744955
关键词
Aspergillus fumigatus; antifungal susceptibility; cyp51A; cyp51B; multicentre
We investigated the antifungal susceptibilities and the cyp51 mutant strains among Aspergillus fumigatus clinical isolates obtained from 10 university hospitals in Korea. Of the 84 isolates examined, two itraconazole-resistant isolates were found with no amino acid substitution in the cyp51A/cyp51B genes. However, 19 (23.2%) azole-susceptible isolates harbored amino acid substitutions: Nine isolates harbored one to five mutations in cyp51A with high polymorphism, and 11 isolates exhibited the same Q42L mutation in cyp51B. Overall, a low azole resistance rate and high frequency of cyp51A/cyp51B amino acid substitutions were observed in the azole-susceptible A. fumigatus isolates in Korea.
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