期刊
JOURNAL OF PAIN RESEARCH
卷 13, 期 -, 页码 927-936出版社
DOVE MEDICAL PRESS LTD
DOI: 10.2147/JPR.S232081
关键词
trigeminal neuralgia; trigeminal post-herpetic neuralgia; ozone therapy; Gasserian ganglion
资金
- National Natural Science Foundation of China [81671076]
- Chaoyang District Commission of Science and Technology of Beijing Municipality [SYSF1830]
Background: Ozone injection around Gasserian ganglion (OIAGG) has been reported to be an effective treatment for trigeminal neuralgia (TN); however, there remain areas for improvement. To overcome one of these limitations, a multicenter examination of application would be extremely helpful. Objective: The goal of this report was to assess the efficacy of OIAGG for refractory TN across multiple centers and to explore factors predictive of successful treatment. Design: A multicenter, retrospective study. Setting: The study was conducted across 3 pain centers across China. Patients and Methods: A total of 103 subjects from 3 pain centers were enrolled in the study. An ozone-oxygen mixture gas at a concentration of 30 mu g/mL was injected into the area around the Gasserian ganglion performed under C-arm X-ray guidance. Primary outcome measures included a pain assessment using a visual analog scale (VAS) and the Barrow Neurological Institute (BNI) pain intensity scale. Clinical assessment of patients for these outcome measures was performed at pretreatment, post-treatment, 6 months, 1 year and 2 years after the OIAGG. Results: Successful pain relief was defined as a score within BNI grades I-IIIa. The pain relief rates at post-treatment, 6 months, 1 year and 2 years after the procedure were 88.35%, 86.87%, 84.46% and 83.30%, respectively. The VAS at each observation time point was significantly different from the preoperative levels (P<0.05). Logistic regression analysis showed that previous nerve damage had a significant effect on the treatment results. No significant complications or side effects were found during or after treatment. Conclusion: This multicenter research confirms our previous single center results that OIAGG is both effective and safe for patients with TN.
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