期刊
BLOOD
卷 125, 期 23, 页码 3536-3541出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-11-575357
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资金
- National Institutes of Health National Heart, Lung, and Blood Institute [R01HL044491]
- National Insitute of Diabetes and Digestive and Kidney Diseases [R01 DK089439]
- National Heart, Lung, and Blood Institute [F32 HL120596]
As essential mediators of red cell production, erythropoietin (EPO) and its cell surface receptor (EPO receptor [EPOR]) have been intensely studied. Early investigations defined basic mechanisms for hypoxia-inducible factor induction of EPO expression, and within erythroid progenitors EPOR engagement of canonical Janus kinase 2/signal transducer and activator of transcription 5 (JAK2/STAT5), rat sarcoma/mitogen-activated protein kinase/extracellular signal-regulated kinase (RAS/MEK/ERK), and phosphatidylinositol 3-kinase (PI3K) pathways. Contemporary genetic, bioinformatic, and proteomic approaches continue to uncover new clinically relevant modulators of EPO and EPOR expression, and EPO's biological effects. This Spotlight review highlights such factors and their emerging roles during erythropoiesis and anemia.
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