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CANCER IMMUNOLOGY RESEARCH (2017)
The STING agonist DMXAA triggers a cooperation between T lymphocytes and myeloid cells that leads to tumor regression
Julia M. Weiss et al.
ONCOIMMUNOLOGY (2017)
Dengue virus NS2B protein targets cGAS for degradation and prevents mitochondrial DNA sensing during infection
Sebastian Aguirre et al.
NATURE MICROBIOLOGY (2017)
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR
Hui Feng et al.
NATURE IMMUNOLOGY (2017)
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt et al.
CELL (2017)
STING Senses Microbial Viability to Orchestrate Stress-Mediated Autophagy of the Endoplasmic Reticulum
Julien Moretti et al.
CELL (2017)
cGAS is activated by DNA in a length-dependent manner
Stefanie Luecke et al.
EMBO REPORTS (2017)
Ubiquitination of STING at lysine 224 controls IRF3 activation
Guoxin Ni et al.
SCIENCE IMMUNOLOGY (2017)
STING-IRF3 Triggers Endothelial Inflammation in Response to Free Fatty Acid-Induced Mitochondrial Damage in Diet-Induced Obesity
Yun Mao et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2017)
Induction of necroptotic cell death by viral activation of the RIG-I or STING pathway
Suruchi N. Schock et al.
CELL DEATH AND DIFFERENTIATION (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
Human Cytomegalovirus Tegument Protein UL82 Inhibits STING-Mediated Signaling to Evade Antiviral Immunity
Yu-Zhi Fu et al.
CELL HOST & MICROBE (2017)
Immunogenic cell death in cancer and infectious disease
Lorenzo Galluzzi et al.
NATURE REVIEWS IMMUNOLOGY (2017)
The Chlamydia trachomatis Inclusion Membrane Protein CpoS Counteracts STING-Mediated Cellular Surveillance and Suicide Programs
Barbara S. Sixt et al.
CELL HOST & MICROBE (2017)
Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors
Jason R. Baird et al.
CANCER RESEARCH (2016)
Yersinia YopJ negatively regulates IRF3-mediated antibacterial response through disruption of STING-mediated cytosolic DNA signaling
Ye Cao et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2016)
Recurrent Loss of STING Signaling in Melanoma Correlates with Susceptibility to Viral Oncolysis
Tianli Xia et al.
CANCER RESEARCH (2016)
Agonist-Mediated Activation of STING Induces Apoptosis in Malignant B Cells
Chih-Hang Anthony Tang et al.
CANCER RESEARCH (2016)
Personalized Immunomonitoring Uncovers Molecular Networks that Stratify Lupus Patients (vol 165, pg 551, 2016)
Romain Banchereau et al.
CELL (2016)
STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection
Xin Wang et al.
CELL HOST & MICROBE (2016)
Group B Streptococcus Degrades Cyclic-di-AMP to Modulate STING-Dependent Type I Interferon Production
Warrison A. Andrade et al.
CELL HOST & MICROBE (2016)
cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites
Shuting Xu et al.
Cell Host & Microbe (2016)
NLRX1 Sequesters STING to Negatively Regulate the Interferon Response, Thereby Facilitating the Replication of HIV-1 and DNA Viruses
Haitao Guo et al.
CELL HOST & MICROBE (2016)
TRIM9 short isoform preferentially promotes DNA and RNA virus-induced production of type I interferon by recruiting GSK3β to TBK1
Yunfei Qin et al.
CELL RESEARCH (2016)
USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA
Man Zhang et al.
CELL RESEARCH (2016)
Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response
Karen J. Mackenzie et al.
EMBO JOURNAL (2016)
Human plasmacytoid dentritic cells elicit a Type I Interferon response by sensing DNA via the cGAS-STING signaling pathway
Christian Bode et al.
EUROPEAN JOURNAL OF IMMUNOLOGY (2016)
The DNA Structure-Specific Endonuclease MUS81 Mediates DNA Sensor STING-Dependent Host Rejection of Prostate Cancer Cells
Samantha S. W. Ho et al.
IMMUNITY (2016)
Recognition of Endogenous Nucleic Acids by the Innate Immune System
Axel Roers et al.
IMMUNITY (2016)
Cross-Regulation of Two Type I Interferon Signaling Pathways in Plasmacytoid Dendritic Cells Controls Anti-malaria Immunity and Host Mortality
Xiao Yu et al.
IMMUNITY (2016)
Sumoylation Promotes the Stability of the DNA Sensor cGAS and the Adaptor STING to Regulate the Kinetics of Response to DNA Virus
Ming-Ming Hu et al.
IMMUNITY (2016)
Growing tumors induce a local STING dependent Type I IFN response in dendritic cells
Lisa Andzinsk et al.
INTERNATIONAL JOURNAL OF CANCER (2016)
Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children
Marie-Louise Fremond et al.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)
LSm14A Plays a Critical Role in Antiviral Immune Responses by Regulating MITA Level in a Cell-Specific Manner
Tian-Tian Liu et al.
JOURNAL OF IMMUNOLOGY (2016)
Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA
Leticia Corrales et al.
JOURNAL OF IMMUNOLOGY (2016)
TRIM14 Inhibits cGAS Degradation Mediated by Selective Autophagy Receptor p62 to Promote Innate Immune Responses
Meixin Chen et al.
MOLECULAR CELL (2016)
Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer
Qing Chen et al.
NATURE (2016)
HIV-1 uses dynamic capsid pores to import nucleotides and fuel encapsidated DNA synthesis
David A. Jacques et al.
NATURE (2016)
S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3
Fuan Wang et al.
NATURE IMMUNOLOGY (2016)
iRhom2 is essential for innate immunity to DNA viruses by mediating trafficking and stability of the adaptor STING
Wei-Wei Luo et al.
NATURE IMMUNOLOGY (2016)
p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity
Carmen Adriaens et al.
NATURE MEDICINE (2016)
Neutrophil extracellular traps enriched in oxidized mitochondrial DNA are interferogenic and contribute to lupus-like disease
Christian Lood et al.
NATURE MEDICINE (2016)
Cre-dependent DNA recombination activates a STING-dependent innate immune response
Genevieve Pepin et al.
NUCLEIC ACIDS RESEARCH (2016)
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
Guigen Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
How neuroinflammation contributes to neurodegeneration
Richard M. Ransohoff
SCIENCE (2016)
Type I/II Interferon Balance in the Regulation of Brain Physiology and Pathology
Aleksandra Deczkowska et al.
TRENDS IN IMMUNOLOGY (2016)
Viral DNA Sensors IFI16 and Cyclic GMP-AMP Synthase Possess Distinct Functions in Regulating Viral Gene Expression, Immune Defenses, and Apoptotic Responses during Herpesvirus Infection
Benjamin A. Diner et al.
MBIO (2016)
Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses
Christian K. Holm et al.
NATURE COMMUNICATIONS (2016)
Activation of STING requires palmitoylation at the Golgi
Kojiro Mukai et al.
NATURE COMMUNICATIONS (2016)
Sensing of HSV-1 by the cGAS-STING pathway in microglia orchestrates antiviral defence in the CNS
Line S. Reinert et al.
NATURE COMMUNICATIONS (2016)
Restriction by SAMHD1 Limits cGAS/STING-Dependent Innate and Adaptive Immune Responses to HIV-1
Jonathan Maelfait et al.
CELL REPORTS (2016)
Tumor cell-derived microparticles polarize M2 tumor-associated macrophages for tumor progression
Ruihua Ma et al.
ONCOIMMUNOLOGY (2016)
Mitochondrial DNA has a pro-inflammatory role in AMD
Bernard Dib et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2015)
PQBP1 Is a Proximal Sensor of the cGAS-Dependent Innate Response to HIV-1
Sunnie M. Yoh et al.
CELL (2015)
STING Activation by Translocation from the ER Is Associated with Infection and Autoinflammatory Disease
Nicole Dobbs et al.
CELL HOST & MICROBE (2015)
Mycobacterium tuberculosis Differentially Activates cGAS- and Inflammasome-Dependent Intracellular Immune Responses through ESX-1
Ruth Wassermann et al.
CELL HOST & MICROBE (2015)
Inhibition of cGAS DNA Sensing by a Herpesvirus Virion Protein
Jian-jun Wu et al.
CELL HOST & MICROBE (2015)
Positive feedback regulation of type I interferon by the interferon-stimulated gene STING
Feng Ma et al.
EMBO REPORTS (2015)
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
Anetta Hartlova et al.
IMMUNITY (2015)
Sequential Activation of Two Pathogen-Sensing Pathways Required for Type I Interferon Expression and Resistance to an Acute DNA Virus Infection
Ren-Huan Xu et al.
IMMUNITY (2015)
Positive Feedback Regulation of Type I IFN Production by the IFN-Inducible DNA Sensor cGAS
Feng Ma et al.
JOURNAL OF IMMUNOLOGY (2015)
Autophagy mediates degradation of nuclear lamina
Zhixun Dou et al.
NATURE (2015)
Mitochondrial DNA stress primes the antiviral innate immune response
A. Phillip West et al.
NATURE (2015)
Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA
Anna-Maria Herzner et al.
NATURE IMMUNOLOGY (2015)
CD47 blockade triggers T cell-mediated destruction of immunogenic tumors
Xiaojuan Liu et al.
NATURE MEDICINE (2015)
A bacterial cyclic dinucleotide activates the cytosolic surveillance pathway and mediates innate resistance to tuberculosis
Bappaditya Dey et al.
NATURE MEDICINE (2015)
The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson's Disease
Alicia M. Pickrell et al.
NEURON (2015)
STING activation of tumor endothelial cells initiates spontaneous and therapeutic antitumor immunity
Olivier Demaria et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases
Daxing Gao et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Modulation of the cGAS-STING DNA sensing pathway by gammaherpesviruses
Zhe Ma et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
cGAS-mediated stabilization of IFI16 promotes innate signaling during herpes simplex virus infection
Megan H. Orzalli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Viruses transfer the antiviral second messenger cGAMP between cells
A. Bridgeman et al.
SCIENCE (2015)
Transmission of innate immune signaling by packaging of cGAMP in viral particles
Matteo Gentili et al.
SCIENCE (2015)
DNA tumor virus oncogenes antagonize the cGAS-STING DNA-sensing pathway
Laura Lau et al.
SCIENCE (2015)
Phosphorylation of innate immune adaptor proteins MAVS, STING, and TRIF induces IRF3 activation
Siqi Liu et al.
SCIENCE (2015)
UPR, autophagy, and mitochondria crosstalk underlies the ER stress response
Daniela Senft et al.
TRENDS IN BIOCHEMICAL SCIENCES (2015)
Priming the Inflammatory Puma of the CNS ater Traumatic Brain Injury
Kristina G. Witcher et al.
TRENDS IN NEUROSCIENCES (2015)
Bacterial c-di-GMP Affects Hematopoietic Stem/Progenitors and Their Niches through STING
Hiroshi Kobayashi et al.
CELL REPORTS (2015)
DNA-Damage-Induced Type I Interferon Promotes Senescence and Inhibits Stem Cell Function
Qiujing Yu et al.
CELL REPORTS (2015)
Akt Kinase-Mediated Checkpoint of cGAS DNA Sensing Pathway
Gil Ju Seo et al.
CELL REPORTS (2015)
Induction of Interferon-Stimulated Genes by IRF3 Promotes Replication of Toxoplasma gondii
Tanmay Majumdar et al.
PLOS PATHOGENS (2015)
TRIM30α Is a Negative-Feedback Regulator of the Intracellular DNA and DNA Virus-Triggered Response by Targeting STING
Yanming Wang et al.
PLOS PATHOGENS (2015)
PPM1A Regulates Antiviral Signaling by Antagonizing TBK1-Mediated STING Phosphorylation and Aggregation
Zexing Li et al.
PLOS PATHOGENS (2015)
Stimulator of Interferon Genes-Associated Vasculopathy With Onset in Infancy A Mimic of Childhood Granulomatosis With Polyangiitis
Justine Munoz et al.
JAMA DERMATOLOGY (2015)
Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways
Yinghui Liu et al.
JOURNAL OF VIROLOGY (2015)
Aicardi-Goutieres syndrome and the type I interferonopathies
Yanick J. Crow et al.
NATURE REVIEWS IMMUNOLOGY (2015)
Obsessive-Compulsive Disorder Is Associated With Broad Impairments in Executive Function: A Meta-Analysis
Hannah R. Snyder et al.
CLINICAL PSYCHOLOGICAL SCIENCE (2015)
RAE1 Ligands for the NKG2D Receptor Are Regulated by STING-Dependent DNA Sensor Pathways in Lymphoma
Adeline R. Lam et al.
CANCER RESEARCH (2014)
Apoptotic Caspases Suppress mtDNA-Induced STING-Mediated Type I IFN Production
Michael J. White et al.
CELL (2014)
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Anthony Rongvaux et al.
CELL (2014)
The ER-Associated Protein ZDHHC1 Is a Positive Regulator of DNA Virus-Triggered, MITA/STING-Dependent Innate Immune Signaling
Qian Zhou et al.
CELL HOST & MICROBE (2014)
Crosstalk between the cGAS DNA Sensor and Beclin-1 Autophagy Protein Shapes Innate Antimicrobial Immune Responses
Qiming Liang et al.
CELL HOST & MICROBE (2014)
Cytosolic RNA:DNA hybrids activate the cGAS-STING axis
Arun K. Mankan et al.
EMBO JOURNAL (2014)
The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING
Qiang Wang et al.
IMMUNITY (2014)
STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors
Seng-Ryong Woo et al.
IMMUNITY (2014)
STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors
Liufu Deng et al.
IMMUNITY (2014)
NLRC3, a Member of the NLR Family of Proteins, Is a Negative Regulator of Innate Immune Signaling Induced by the DNA Sensor STING
Lu Zhang et al.
IMMUNITY (2014)
Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations
Nadia Jeremiah et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
STING-Mediated DNA Sensing Promotes Antitumor and Autoimmune Responses to Dying Cells
Jared Klarquist et al.
JOURNAL OF IMMUNOLOGY (2014)
Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis
Henrique Lemos et al.
JOURNAL OF IMMUNOLOGY (2014)
Pan-viral specificity of IFN-induced genes reveals new roles for cGAS in innate immunity
John W. Schoggins et al.
NATURE (2014)
Hydrolysis of 2′3′-cGAMP by ENPP1 and design of nonhydrolyzable analogs
Lingyin Li et al.
NATURE CHEMICAL BIOLOGY (2014)
Self-consumption: the interplay of autophagy and apoptosis
Guillermo Marino et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)
Activated STING in a Vascular and Pulmonary Syndrome
Y. Liu et al.
NEW ENGLAND JOURNAL OF MEDICINE (2014)
Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs
Maria Kalamvoki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Nucleic acid sensing by T cells initiates Th2 cell differentiation
Takayuki Imanishi et al.
NATURE COMMUNICATIONS (2014)
Inflammation-driven carcinogenesis is mediated through STING
Jeonghyun Ahn et al.
NATURE COMMUNICATIONS (2014)
The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop
Xu Zhang et al.
CELL REPORTS (2014)
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA
Pu Gao et al.
CELL REPORTS (2014)
Dnase2a Deficiency Uncovers Lysosomal Clearance of Damaged Nuclear DNA via Autophagy
Yuk Yuen Lan et al.
CELL REPORTS (2014)
STING-Dependent Type I IFN Production Inhibits CellMediated Immunity to Listeria monocytogenes
Kristina A. Archer et al.
PLOS PATHOGENS (2014)
RNF26 Temporally Regulates Virus-Triggered Type I Interferon Induction by Two Distinct Mechanisms
Yue Qin et al.
PLOS PATHOGENS (2014)
SARS coronavirus papain-like protease inhibits the type I interferon signaling pathway through interaction with the STING-TRAF3-TBK1 complex
Xiaojuan Chen et al.
PROTEIN & CELL (2014)
STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Takayuki Ohkuri et al.
CANCER IMMUNOLOGY RESEARCH (2014)
STING Ligand c-di-GMP Improves Cancer Vaccination against Metastatic Breast Cancer
Dinesh Chandra et al.
CANCER IMMUNOLOGY RESEARCH (2014)
Assembly and localization of Toll-like receptor signalling complexes
Nicholas J. Gay et al.
NATURE REVIEWS IMMUNOLOGY (2014)
An expression atlas of human primary cells: inference of gene function from coexpression networks
Neil A. Mabbott et al.
BMC GENOMICS (2013)
Chromatin Remodeling at DNA Double-Strand Breaks
Brendan D. Price et al.
CELL (2013)
Host Restriction Factor SAMHD1 Limits Human T Cell Leukemia Virus Type 1 Infection of Monocytes via STING-Mediated Apoptosis
Alexandre Sze et al.
CELL HOST & MICROBE (2013)
Species-specific detection of the antiviral small-molecule compound CMA by STING
Taner Cavlar et al.
EMBO JOURNAL (2013)
Hepatitis C virus NS4B protein targets STING and abrogates RIG-I-mediated type I interferon-dependent innate immunity
Sayuri Nitta et al.
HEPATOLOGY (2013)
Cyclic GMP-AMP Synthase Is Activated by Double-Stranded DNA-Induced Oligomerization
Xin Li et al.
IMMUNITY (2013)
The Capsids of HIV-1 and HIV-2 Determine Immune Detection of the Viral cDNA by the Innate Sensor cGAS in Dendritic Cells
Xavier Lahaye et al.
IMMUNITY (2013)
Oxidative Damage of DNA Confers Resistance to Cytosolic Nuclease TREX1 Degradation and Potentiates STING-Dependent Immune Sensing
Nadine Gehrke et al.
IMMUNITY (2013)
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity
Qiang Ding et al.
JOURNAL OF HEPATOLOGY (2013)
Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING
Xu Zhang et al.
MOLECULAR CELL (2013)
HIV-1 evades innate immune recognition through specific cofactor recruitment
Jane Rasaiyaah et al.
NATURE (2013)
cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING
Andrea Ablasser et al.
NATURE (2013)
Structural mechanism of cytosolic DNA sensing by cGAS
Filiz Civril et al.
NATURE (2013)
Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP
Andrea Ablasser et al.
NATURE (2013)
Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway
Lijun Sun et al.
SCIENCE (2013)
Pivotal Roles of cGAS-cGAMP Signaling in Antiviral Defense and Immune Adjuvant Effects
Xiao-Dong Li et al.
SCIENCE (2013)
Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses
Daxing Gao et al.
SCIENCE (2013)
Structure of Human cGAS Reveals a Conserved Family of Second-Messenger Enzymes in Innate Immunity
Philip J. Kranzusch et al.
CELL REPORTS (2013)
The role of dendritic cells in autoimmunity
Dipyaman Ganguly et al.
NATURE REVIEWS IMMUNOLOGY (2013)
ATM and the Molecular Pathogenesis of Ataxia Telangiectasia
Peter J. McKinnon
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 (2012)
Tuberculosis Pathogenesis and Immunity
Jennifer A. Philips et al.
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 7 (2012)
Cytosolic sensing of extracellular self-DNA transported into monocytes by the antimicrobial peptide LL37
Georgios Chamilos et al.
BLOOD (2012)
Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway
Robert O. Watson et al.
CELL (2012)
Engineering DNA Nanoparticles as Immunomodulatory Reagents that Activate Regulatory T Cells
Lei Huang et al.
JOURNAL OF IMMUNOLOGY (2012)
Inhibition of HIV-1 Disease Progression by Contemporaneous HIV-2 Infection
Joakim Esbjornsson et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Nuclear IFI16 induction of IRF-3 signaling during herpesviral infection and degradation of IFI16 by the viral ICP0 protein
Megan H. Orzalli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
STING Specifies IRF3 Phosphorylation by TBK1 in the Cytosolic DNA Signaling Pathway
Yasuo Tanaka et al.
SCIENCE SIGNALING (2012)
DENV Inhibits Type I IFN Production in Infected Cells by Cleaving Human STING
Sebastian Aguirre et al.
PLOS PATHOGENS (2012)
Immunomodulatory functions of type I interferons
Jose M. Gonzalez-Navajas et al.
NATURE REVIEWS IMMUNOLOGY (2012)
Randomized Phase III Placebo-Controlled Trial of Carboplatin and Paclitaxel With or Without the Vascular Disrupting Agent Vadimezan (ASA404) in Advanced Non-Small-Cell Lung Cancer
Primo N. Lara et al.
JOURNAL OF CLINICAL ONCOLOGY (2011)
Host type I IFN signals are required for antitumor CD8+ T cell responses through CD8α+ dendritic cells
Mercedes B. Fuertes et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2011)
STING is a direct innate immune sensor of cyclic di-GMP
Dara L. Burdette et al.
NATURE (2011)
SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx
Nadine Laguette et al.
NATURE (2011)
Netting Neutrophils Are Major Inducers of Type I IFN Production in Pediatric Systemic Lupus Erythematosus
Gina S. Garcia-Romo et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Modulation of the immune system by UV radiation: more than just the effects of vitamin D?
Prue H. Hart et al.
NATURE REVIEWS IMMUNOLOGY (2011)
Glycogen Synthase Kinase 3β Regulates IRF3 Transcription Factor-Mediated Antiviral Response via Activation of the Kinase TBK1
Cao-Qi Lei et al.
IMMUNITY (2010)
The Ubiquitin Ligase TRIM56 Regulates Innate Immune Responses to Intracellular Double-Stranded DNA
Tetsuo Tsuchida et al.
IMMUNITY (2010)
IFI16 is an innate immune sensor for intracellular DNA
Leonie Unterholzner et al.
NATURE IMMUNOLOGY (2010)
Mitochondria and cell death: outer membrane permeabilization and beyond
Stephen W. G. Tait et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
c-di-AMP Secreted by Intracellular Listeria monocytogenes Activates a Host Type I Interferon Response
Joshua J. Woodward et al.
SCIENCE (2010)
The Ubiquitin Ligase RNF5 Regulates Antiviral Responses by Mediating Degradation of the Adaptor Protein MITA
Bo Zhong et al.
IMMUNITY (2009)
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
Veit Hornung et al.
NATURE (2009)
STING regulates intracellular DNA-mediated, type I interferon-dependent innate immunity
Hiroki Ishikawa et al.
NATURE (2009)
Atg9a controls dsDNA-driven dynamic translocation of STING and the innate immune response
Tatsuya Saitoh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
ERIS, an endoplasmic reticulum IFN stimulator, activates innate immune signaling through dimerization
Wenxiang Sun et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation
Bo Zhong et al.
IMMUNITY (2008)
STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling
Hiroki Ishikawa et al.
NATURE (2008)
Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor
Jean-Philippe Coppe et al.
PLOS BIOLOGY (2008)
p16INK4a induces an age-dependent decline in islet regenerative potential
Janakiraman Krishnamurthy et al.
NATURE (2006)
Induction of dendritic cell differentiation by IFN-α in systemic lupus erythematosus
P Blanco et al.
SCIENCE (2001)
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