期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.00572
关键词
mouse; model; transplantation; immunology; metabolism; costimulation blockade; rejection
类别
资金
- US National Institutes of Health [R01AI077610]
- Bloomberg-Kimmel Institute of Cancer Immunotherapy
- DOD [W81XWH-17-10624 RT160075, W81XWH-17-1-0520]
Transplant tolerance in the absence of long-term immunosuppression has been an elusive goal for solid organ transplantation. Recently, it has become clear that metabolic reprogramming plays a critical role in promoting T cell activation, differentiation, and function. Targeting metabolism can preferentially inhibit T cell effector generation while simultaneously promoting the generation of T regulatory cells. We hypothesized that costimulatory blockade with CTLA4Ig in combination with targeting T cell metabolism might provide a novel platform to promote the induction of transplant tolerance.
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