期刊
FRONTIERS IN IMMUNOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2020.00604
关键词
exosomal PD-L1; biogenesis; immunosuppression; T cells; biomarker; immunotherapy
类别
资金
- National Natural Science Foundation of China [81972636, 81872281, 81472595]
- Natural Science Foundation of Hunan Province [2019JJ40175, 2019JJ40183, 2018JJ3634, 2018JJ1013]
- Research Projects of Health Commission of Hunan Province [20201772, B20180400, B20180582]
- Research Projects of Health Department of Hunan Province [B2013-096]
- Changsha Science and Technology Project [kq1901071, kq1901072, kq1706045, kq1706043]
- Ascend Foundation of National cancer center [NCC2018b68]
- Humanities and Social Science Youth Fund of Ministry of Education of China [19YJCZH254]
The exosome serves as a trafficking vehicle for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells by exosomal PD-L1. Here, we summerize the biogenesis and transport process of exosomal PD-L1. Then, we focus on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlight the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we discuss the new challenges faced in researching and utilizing exosomal PD-L1. This review may shed light on the exosomal PD-L1 from the bench to the clinic. Exosomes serve as trafficking vehicles for transport of programmed death-ligand 1 (PD-L1) into receptor cells. In tumor microenvironment, distant tumor cells can remotely attack activated T cells through exosomal PD-L1. Here, we have summarized the biogenesis and transport of exosomal PD-L1. Next, we focused on the cancer biology of exosomal PD-L1 in immunosuppression and the mechanism by which it inhibits T cells. Finally, we highlighted the prospects of exosomal PD-L1 as a tumor biomarker and its significance in immunotherapy. In addition, we have discussed the new challenges faced in studying and utilizing exosomal PD-L1. This review may shed light on the translation of exosomal PD-L1 from bench to clinic.
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