期刊
APPLIED SCIENCES-BASEL
卷 10, 期 8, 页码 -出版社
MDPI
DOI: 10.3390/app10082649
关键词
insulin; mucin; polyethylene glycol; microparticles; toxicology
类别
资金
- Tertiary Education Trust Fund (TETFUND)-National Research Fund (NFR) of Nigeria [TETFUND/DESS/NRF/STI/13/VOL.1]
In this study, different ratios of mucin-grafted polyethylene-glycol-based microparticles were prepared and evaluated both in vitro and in vivo as carriers for the oral delivery of insulin. Characterization measurements showed that the insulin-loaded microparticles display irregular porosity and shape. The encapsulation efficiency and loading capacity of insulin were >82% and 18%, respectively. The release of insulin varied between 68% and 92% depending on the microparticle formulation. In particular, orally administered insulin-loaded microparticles resulted in a significant fall of blood glucose levels, as compared to insulin solution. Subcutaneous administration showed a faster, albeit not sustained, glucose fall within a short time as compared to the polymeric microparticle-based formulations. These results indicate the possible oral delivery of insulin using this combination of polymers.
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