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FREE RADICAL BIOLOGY AND MEDICINE (2017)
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JOURNAL OF PHARMACY AND PHARMACOLOGY (2017)
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JOURNAL OF SURGICAL RESEARCH (2017)
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JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2017)
Emerging Anti-Mitotic Activities and Other Bioactivities of Sesquiterpene Compounds upon Human Cells
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PHYTOTHERAPY RESEARCH (2017)
Parthenolide Selectively Sensitizes Prostate Tumor Tissue to Radiotherapy while Protecting Healthy Tissues In Vivo
Katherine L. Morel et al.
RADIATION RESEARCH (2017)
Application of oxygen/nitrogen substituted donor-acceptor cyclopropanes in the total synthesis of natural products
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TETRAHEDRON LETTERS (2017)
Differential effects of Helenalin, an anti-inflammatory sesquiterpene lactone, on the proteome, metabolome and the oxidative stress response in several immune cell types
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TOXICOLOGY IN VITRO (2017)
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PLOS ONE (2017)
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AMERICAN JOURNAL OF THERAPEUTICS (2016)
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Developmental and Environmental Effects on Sesquiterpene Lactones in Cultivated Arnicamontana L.
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CHEMISTRY & BIODIVERSITY (2016)
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CURRENT MEDICINAL CHEMISTRY (2016)
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ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY (2016)
Chemical modification of arglabin and biological activity of its new derivatives
S. M. Adekenov
FITOTERAPIA (2016)
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FITOTERAPIA (2016)
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INDUSTRIAL CROPS AND PRODUCTS (2016)
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INTERNATIONAL IMMUNOPHARMACOLOGY (2016)
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JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH (2016)
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JOURNAL OF NEUROSCIENCE (2016)
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NEURAL REGENERATION RESEARCH (2016)
Thapsigargin-induced activation of Ca2+-CaMKII-ERK in brainstem contributes to substance P release and induction of emesis in the least shrew
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NEUROPHARMACOLOGY (2016)
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CELL DEATH & DISEASE (2016)
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CELL DEATH & DISEASE (2016)
Cynaropicrin : A Comprehensive Research Review and Therapeutic Potential As an Anti-Hepatitis C Virus Agent
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FRONTIERS IN PHARMACOLOGY (2016)
Alantolactone selectively suppresses STAT3 activation and exhibits potent anticancer activity in MDA-MB-231 cells
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CANCER LETTERS (2015)
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CHEMICO-BIOLOGICAL INTERACTIONS (2015)
Metabolomic Profile of the Genus Inula
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CHEMISTRY & BIODIVERSITY (2015)
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CIRCULATION (2015)
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EUROPEAN JOURNAL OF PHARMACOLOGY (2015)
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INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2015)
Potential Anti-Cancer Activities and Mechanisms of Costunolide and Dehydrocostuslactone
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INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2015)
The Synergistic Effect of SAHA and Parthenolide in MDA-MB231 Breast Cancer Cells
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JOURNAL OF CELLULAR PHYSIOLOGY (2015)
Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers
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JOURNAL OF DERMATOLOGICAL SCIENCE (2015)
Syntheses and Biological Evaluation of Costunolide, Parthenolide, and Their Fluorinated Analogues
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JOURNAL OF MEDICINAL CHEMISTRY (2015)
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NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2015)
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NEUROTOXICOLOGY (2015)
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PHYTOTHERAPY RESEARCH (2015)
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PLANT SCIENCE (2015)
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STEROIDS (2015)
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TETRAHEDRON LETTERS (2015)
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TETRAHEDRON LETTERS (2015)
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CELL DEATH & DISEASE (2015)
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ONCOLOGY LETTERS (2015)
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INTERNATIONAL JOURNAL OF ONCOLOGY (2015)
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RSC ADVANCES (2015)
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BIOLOGICAL & PHARMACEUTICAL BULLETIN (2014)
Poly(styrene-alt-maleic anhydride)-Based Diblock Copolymer Micelles Exhibit Versatile Hydrophobic Drug Loading, Drug-Dependent Release, and Internalization by Multidrug Resistant Ovarian Cancer Cells
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BIOMACROMOLECULES (2014)
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2014)
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JOURNAL OF ETHNOPHARMACOLOGY (2014)
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Design and synthesis of spiro derivatives of parthenin as novel anti-cancer agents
Doma Mahendhar Reddy et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Lettuce Costunolide Synthase (CYP71BL2) and Its Homolog (CYP71BL1) from Sunflower Catalyze Distinct Regio- and Stereoselective Hydroxylations in Sesquiterpene Lactone Metabolism
Nobuhiro Ikezawa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Parthenolide Sensitizes Hepatocellular Carcinoma Cells to TRAIL by Inducing the Expression of Death Receptors Through Inhibition of STAT3 Activation
Daniela Carlisi et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2011)
Parthenolide inhibits ERK and AP-1 which are dysregulated and contribute to excessive IL-8 expression and secretion in cystic fibrosis cells
Aicha Saadane et al.
JOURNAL OF INFLAMMATION-LONDON (2011)
Pilot study of the efficacy and safety of lettuce seed oil in patients with sleep disorders
Mostafa Yakoot et al.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE (2011)
Surface plasmon resonance analysis of nuclear factor-κB protein interactions with the sesquiterpene lactone helenalin
Berthold Buechele et al.
ANALYTICAL BIOCHEMISTRY (2010)
Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase
Dorthe Mondrup Skytte et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Role of nuclear factor kappa B in cardiovascular health and disease
Kim Van der Heiden et al.
CLINICAL SCIENCE (2010)
What made sesquiterpene lactones reach cancer clinical trials?
Akram Ghantous et al.
DRUG DISCOVERY TODAY (2010)
Enhancement of parthenolide-induced apoptosis by a PKC-alpha inhibition through heme oxygenase-1 blockage in cholangiocarcinoma cells
Bo-Ra Yun et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2010)
Sesquiterpene lactone trilobolide activates production of interferon-γ and nitric oxide
Eva Kmonickova et al.
FITOTERAPIA (2010)
Ultrasound-assisted extraction of alantolactone and isoalantolactone from Inula helenium roots
Antoaneta Trendafilova et al.
PHARMACOGNOSY MAGAZINE (2010)
Aminoparthenolides as novel anti-leukemic agents: Discovery of the NF-κB inhibitor, DMAPT (LC-1)
Sundar Neelakantan et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Antipyretic and anti-inflammatory properties of the ethanolic extract, dichloromethane fraction and costunolide from Magnolia ovata (Magnoliaceae)
Candida Aparecida Leite Kassuya et al.
JOURNAL OF ETHNOPHARMACOLOGY (2009)
Searching for NF-kappa B-Based Treatments of Ischemia Reperfusion Injury
Christopher A. Latanich et al.
JOURNAL OF INVESTIGATIVE SURGERY (2009)
Modulation of DNA Methylation by a Sesquiterpene Lactone Parthenolide
Zhongfa Liu et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms
Carsten Berges et al.
MOLECULAR IMMUNOLOGY (2009)
Sesquiterpene Lactones and Bitterness in Korean Leaf Lettuce Cultivars
Myeong Whoon Seo et al.
HORTSCIENCE (2009)
Antileukemic activity of aminoparthenolide analogs
Shama Nasim et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
The impact of natural products upon modern drug discovery
A. Ganesan
CURRENT OPINION IN CHEMICAL BIOLOGY (2008)
Plants used as remedies antirheumatic and antineuralgic in the traditional medicine of Lebanon
El Beyrouthy Marc et al.
JOURNAL OF ETHNOPHARMACOLOGY (2008)
Effect of Celecoxib and the Novel Anti-Cancer Agent, Dimethylamino-Parthenolide, in a Developmental Model of Pancreatic Cancer
Michele T. Yip-Schneider et al.
PANCREAS (2008)
An orally bioavailable parthenolide analog selectively eradicates acute myelogenous leukemia stem and progenitor cells
Monica L. Guzman et al.
BLOOD (2007)
Parthenolide induces significant apoptosis and production of reactive oxygen species in high-risk pre-B leukemia cells
Susan J. Zunino et al.
CANCER LETTERS (2007)
Toxicological evaluation of a chicory root extract
Barbara M. Schmidt et al.
FOOD AND CHEMICAL TOXICOLOGY (2007)
Parthenolide specifically depletes histone deacetylase 1 protein and induces cell death through ataxia telangiectasia mutated
Yx Vashisht Gopal et al.
CHEMISTRY & BIOLOGY (2007)
Novel neuroprotective compound SCH-20148 rescues thymocytes and SH-SY5Y cells from thapsigargin-induced mitochondrial membrane potential reduction and cell death
Yuko Muramatsu et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2007)
Saussurea costus:: Botanical, chemical and pharmacological review of an ayurvedic medicinal plant
Madan Mohan Pandey et al.
JOURNAL OF ETHNOPHARMACOLOGY (2007)
Choosing between NSAID and arnica for topical treatment of hand osteoarthritis in a randomised, double-blind study
Reto Widrig et al.
RHEUMATOLOGY INTERNATIONAL (2007)
Parthenolide inhibits tubulin carboxypeptidase activity
Xavier Fonrose et al.
CANCER RESEARCH (2007)
Helenalin reduces Staphylococcus aureus infection in vitro and in vivo
D. Boulanger et al.
VETERINARY MICROBIOLOGY (2007)
Enantioselective synthesis of arglabin
Srinivas Kalidindi et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2007)
Antifeedant properties and chemotaxonomic implications of sesquiterpene lactones and syringin from Rhaponticum pulchrum
Joanna Cis et al.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY (2006)
Analgesic and sedative activities of lactucin and some lactucin-like guaianolides in mice
A. Wesolowska et al.
JOURNAL OF ETHNOPHARMACOLOGY (2006)
Extracts of Inula viscosa control downy mildew of grapes caused by Plasmopara viticola
Y Cohen et al.
PHYTOPATHOLOGY (2006)
The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors
LL Wootton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro
A. J. Steele et al.
LEUKEMIA (2006)
Cytotoxic sesquiterpene lactones from Saussurea calcicola
SZ Choi et al.
ARCHIVES OF PHARMACAL RESEARCH (2005)
Potent inhibition of human telomerase by helenalin
PR Huang et al.
CANCER LETTERS (2005)
Susceptibility of cholangiocarcinoma cells to parthenolide-induced apoptosis
JH Kim et al.
CANCER RESEARCH (2005)
Synthetic approaches towards structurally diverse γ-butyrolactone natural-product-like compounds
M Seitz et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2005)
The sesquiterpene lactone parthenolide induces apoptosis of human acute myelogenous leukemia stem and progenitor cells
ML Guzman et al.
BLOOD (2005)
Cytological development and sesquiterpene lactone secretion in capitate glandular trichomes of sunflower
JC Göpfert et al.
PLANT BIOLOGY (2005)
Trypanocidal and antimicrobial activities of Moquinia kingii
EC Schinor et al.
PHYTOMEDICINE (2004)
Antitumor agent parthenolide reverses resistance of breast cancer cells to tumor necrosis factor-related apoptosis-inducing ligand through sustained activation of c-Jun N-terminal kinase
H Nakshatri et al.
ONCOGENE (2004)
Cytotoxic and pro-apoptotic activities of cynaropicrin, a sesquiterpene lactone, on the viability of leukocyte cancer cell lines
JY Cho et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2004)
Prostate-specific antigen-activated thapsigargin prodrug as targeted therapy for prostate cancer
SR Denmeade et al.
JOURNAL OF THE NATIONAL CANCER INSTITUTE (2003)
Inhibition of LPS-induced p42/44 MAP kinase activation and iNOS/NO synthesis by parthenolide in rat primary microglial cells
BL Fiebich et al.
JOURNAL OF NEUROIMMUNOLOGY (2002)
Biosynthesis of costunolide, dihydrocostunolide, and leucodin. Demonstration of cytochrome P450-catalyzed formation of the lactone ring present in sesquiterpene lactones of chicory
JW de Kraker et al.
PLANT PHYSIOLOGY (2002)
Sesquiterpene lactone parthenolide, an inhibitor of IκB kinase complex and nuclear factor-κB, exerts beneficial effects in myocardial reperfusion injury
B Zingarelli et al.
SHOCK (2002)
A mechanistic approach to the in vivo anti-inflammatory activity of sesquiterpenoid compounds isolated from Inula viscosa
V Hernández et al.
PLANTA MEDICA (2001)
Inhibitory effects of helenalin and related compounds on 5-lipoxygenase and leukotriene C4 synthase in human blood cells
S Tornhamre et al.
BIOCHEMICAL PHARMACOLOGY (2001)
Biosynthesis of germacrene A carboxylic acid in chicory roots.: Demonstration of a cytochrome P450 (+)-germacrene A hydroxylase and NADP+-dependent sesquiterpenoid dehydrogenase(s) involved in sesquiterpene lactone biosynthesis
JW de Kraker et al.
PLANT PHYSIOLOGY (2001)
Participation of mitogen-activated protein kinase in thapsigargin- and TPA-induced histamine production in murine macrophage RAW 264.7 cells
M Shiraishi et al.
BRITISH JOURNAL OF PHARMACOLOGY (2000)
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