期刊
ADVANCED SCIENCE
卷 7, 期 12, 页码 -出版社
WILEY
DOI: 10.1002/advs.201903172
关键词
microengineered SERS substrates; microfluidics; multiple detection; SERS barcoding
资金
- European Research Council [677020]
- Swiss National Science Foundation [200021_181988]
- ETH Zurich
- Swiss National Science Foundation (SNF) [200021_181988] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [677020] Funding Source: European Research Council (ERC)
Microfluidic technologies have emerged as advanced tools for surface-enhanced Raman spectroscopy (SERS). They have proved to be particularly appealing for in situ and real-time detection of analytes at extremely low concentrations and down to the 10 x 10(-15) m level. However, the ability to prepare reconfigurable and reusable devices endowing multiple detection capabilities is an unresolved challenge. Herein, a microfluidic-based method that allows an extraordinary spatial control over the localization of multiple active SERS substrates in a single microfluidic channel is presented. It is shown that this technology provides for exquisite control over analyte transport to specific detection points, while avoiding cross-contamination; a feature that enables the simultaneous detection of multiple analytes within the same microfluidic channel. Additionally, it is demonstrated that the SERS substrates can be rationally designed in a straightforward manner and that they allow for the detection of single molecules (at concentrations as low as 10(-14) m). Finally, it is shown that rapid etching and reconstruction of SERS substrates provides for reconfigurable and reusable operation.
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