期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 6, 期 5, 页码 3037-3045出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.9b01997
关键词
bone regeneration; hydrogels; tofu; gelatin methacrylate (GelMa)
资金
- National Natural Science Foundation of China [51503129]
- Guangdong Innovative and Entrepreneurial Research Team Program [2016ZT06S029]
- Science and Technology Program of Guangzhou [201707010094]
- Science and Technology Planning Project of Shenzhen [JCYJ20180307163534533]
Food-derived materials possess inherent advantages in tissue engineering applications with appropriate biosafety, availability, and maneuverability. This work takes advantage of gelatin methacrylate (GelMa) to fabricate the tofu-incorporated hydrogels and systematically investigated the potential for bone regeneration. The results affirmed that tofu-incorporated hydrogel possessed porous architecture, satisfactory mechanical performance, and appropriate cytocompatibility. It is worth noting that little inflammation could be caused by the tofu/GelMa hydrogels, and the incorporated tofu powder could also promote the secretion of osteogenesis and immune-related cytokines in the early stage, resulting in improved bone regeneration during the 2-month implantation. All the results suggested that tofu/GelMa hydrogels possessed good potential for bone regeneration with low cost, satisfactory cytocompatibility, and excellent bioactivity.
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