期刊
CHEMSUSCHEM
卷 9, 期 7, 页码 696-702出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201501654
关键词
catalyst recycling; downstream processing; microreactor; organocatalysis; switchable solvents
资金
- DFG [KR 2491/12-1]
- Switchable Solution Inc
Switchable-hydrophilicity solvents (SHSs) are solvents that can switch reversibly between a water-miscible state to a state that forms a biphasic mixture with water. In this case study, SHSs have been studied for easy product/catalyst separation as well as catalyst recycling. A series of tertiary amine SHSs have been identified for the extraction of the hydrophilic product from the postreaction mixture. Here, we determined high extraction efficiencies for the product (>84%) and low extraction rates for the catalyst (<0.1%). With the catalyst recycling experiments, we isolated the product in high purity (>98%) without further purification steps. At the same time, the catalyst was reused without any loss of activity (>91% enantiomeric excess, >99% yield) four times. Furthermore, we optimized the extraction efficiency by working with a microextractor. In addition, with the use of a falling-film microreactor, we obtained the product with high enantioselectivity by working at ambient conditions.
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