期刊
NANOMATERIALS
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/nano10040744
关键词
mitochondrial function; ceria nanoparticles; gold-supported ceria nanoparticles; antioxidant; triphenylphosphonium gold-supported ceria nanoparticles
类别
资金
- Carlos III Health Institute
- European Regional Development Fund [CP13/00252, PI16/1083]
- Catalonian Agency for Management of University and Research Grants [2017SGR1303]
- Ministry of Education of the Valencian Regional Government [PROMETEO/2019/027]
- Foundation for the Promotion of Health and Biomedical Research of Valencia Region [Nanobetes2]
Ceria nanoparticles are cell compatible antioxidants whose activity can be enhanced by gold deposition and by surface functionalization with positive triphenylphosphonium units to selectively target the mitochondria. The antioxidant properties of these nanoparticles can serve as the basis of a new strategy for the treatment of several disorders exhibiting oxidative stress, such as cancer, diabetes or Alzheimer's disease. However, all of these pathologies require a specific antioxidant according with their mechanism to remove oxidant species excess in cells and diminish their effect on mitochondrial function. The mechanism through which ceria nanoparticles neutralize oxidative stress and their effect on mitochondrial function have not been characterized yet. In the present study, the mitochondria antioxidant effect of ceria and ceria-supported gold nanoparticles, with or without triphenylphosphonium functionalization, was assessed in HeLa cells. The effect caused by ceria nanoparticles on mitochondria function in terms of mitochondrial membrane potential (Delta Psi m), adenosine triphosphate (ATP) production, nuclear respiratory factor 1 (NRF1) and nuclear factor erythroid-2 like 1 (NFE2L1) was reversed by the presence of gold. Furthermore, this effect was enhanced when nanoparticles were functionalized with triphenylphosphonium. Our study illustrates how the mitochondrial antioxidant effect induced by ceria nanoparticles can be modulated by the presence of gold.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据