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Titin stiffness modifies the force-generating region of muscle sarcomeres
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Experimentally Increasing Titin Compliance in a Novel Mouse Model Attenuates the Frank-Starling Mechanism But Has a Beneficial Effect on Diastole
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CIRCULATION (2014)
Deletion of the titin N2B region accelerates myofibrillar force development but does not alter relaxation kinetics
Fatiha Elhamine et al.
JOURNAL OF CELL SCIENCE (2014)
Removal of immunoglobulin-like domains from titin's spring segment alters titin splicing in mouse skeletal muscle and causes myopathy
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JOURNAL OF GENERAL PHYSIOLOGY (2014)
Deleting titin's I-band/A-band junction reveals critical roles for titin in biomechanical sensing and cardiac function
Henk L. Granzier et al.
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Impact of titin isoform on length dependent activation and cross-bridge cycling kinetics in rat skeletal muscle
Ryan D. Mateja et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
Shortening of the Elastic Tandem Immunoglobulin Segment of Titin Leads to Diastolic Dysfunction
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CIRCULATION (2013)
Rbm20 regulates titin alternative splicing as a splicing repressor
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NUCLEIC ACIDS RESEARCH (2013)
Tuning the molecular giant titin through phosphorylation: Role in health and disease
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TRENDS IN CARDIOVASCULAR MEDICINE (2013)
Comprehensive analysis of titin protein isoform and alternative splicing in normal and mutant rats
Shijun Li et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2012)
RBM20, a gene for hereditary cardiomyopathy, regulates titin splicing
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NATURE MEDICINE (2012)
Titin-based tension in the cardiac sarcomere: Molecular origin and physiological adaptations
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Thick-Filament Strain and Interfilament Spacing in Passive Muscle: Effect of Titin-Based Passive Tension
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Titin-Actin Interaction: PEVK-Actin-Based Viscosity in a Large Animal
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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2011)
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JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY (2010)
Excision of titin's cardiac PEVK spring element abolishes PKCα-induced increases in myocardial stiffness
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JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2010)
Differential splicing of the large sarcomeric protein nebulin during skeletal muscle development
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JOURNAL OF STRUCTURAL BIOLOGY (2010)
Truncation of Titin's Elastic PEVK Region Leads to Cardiomyopathy With Diastolic Dysfunction
Henk L. Granzier et al.
CIRCULATION RESEARCH (2009)
PKC Phosphorylation of Titin's PEVK Element A Novel and Conserved Pathway for Modulating Myocardial Stiffness
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CIRCULATION RESEARCH (2009)
Physiological functions of the giant elastic protein titin in mammalian striated muscle
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JOURNAL OF PHYSIOLOGICAL SCIENCES (2008)
Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle
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AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2007)
Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophy
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
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CLINICA CHIMICA ACTA (2007)
CARMA: A platform for analyzing microarray datasets that incorporate replicate measures
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BMC BIOINFORMATICS (2006)
Hierarchical extensibility in the PEVK domain of skeletal-muscle titin
A Nagy et al.
BIOPHYSICAL JOURNAL (2005)
Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium
S Lahmers et al.
CIRCULATION RESEARCH (2004)
Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins
CM Warren et al.
ELECTROPHORESIS (2003)
Molecular mechanics of cardiac titin's PEVK and N2B spring elements
K Watanabe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
The muscular dystrophy with myositis (mdm) mouse mutation disrupts a skeletal muscle-specific domain of titin
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GENOMICS (2002)
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JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY (2002)
Titin and the sarcomere symmetry paradox
AD Liversage et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
Changes in titin and collagen underlie diastolic stiffness diversity of cardiac muscle
YM Wu et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2000)
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