期刊
FRONTIERS IN PHYSIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2020.00509
关键词
lymphatic vessel; endothelial junction; button-like junction; zipper-like junction; VE-cadherin; VEGFR2 signaling
类别
资金
- NIH [R01HL149343-01, R01DK120373-01A1, R01EY025979-01, P30EY026878]
- Leducq Foundation (TNE ATTRACT)
- European Research Council (ERC) [834161]
- Agence nationale de la recherche (ANR Brainwash)
- Fundamental Research Funds for the Central Universities [20ykzd19]
- European Research Council (ERC) [834161] Funding Source: European Research Council (ERC)
Lymphatic endothelial cells (LECs) lining lymphatic vessels develop specialized cell-cell junctions that are crucial for the maintenance of vessel integrity and proper lymphatic vascular functions. Successful lymphatic drainage requires a division of labor between lymphatic capillaries that take up lymph via open button-like junctions, and collectors that transport lymph to veins, which have tight zipper-like junctions that prevent lymph leakage. In recent years, progress has been made in the understanding of these specialized junctions, as a result of the application of state-of-the-art imaging tools and novel transgenic animal models. In this review, we discuss lymphatic development and mechanisms governing junction remodeling between button and zipper-like states in LECs. Understanding lymphatic junction remodeling is important in order to unravel lymphatic drainage regulation in obesity and inflammatory diseases and may pave the way towards future novel therapeutic interventions.
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