期刊
FRONTIERS IN PHYSIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2020.00370
关键词
microbiome; metagenomics; steatosis; AUD; CAP
类别
资金
- NIH [R01 AA24726, U01 AA026939]
- Biomedical Laboratory Research and Development Service of the VA Office of Research and Development [BX004594]
- Fond National de Recherche Scientifique (FNRS), Belgium [PDR T.0217.18]
- [P30 DK120515]
- [P50 AA011999]
Excessive alcohol consumption is associated with hepatic steatosis and dysregulation of the gut microbiota in patients with alcohol use disorder (AUD). However, how gut microbiota responds when patients stop drinking has not been well studied. In this study, we use shotgun metagenomic sequencing to elucidate the alterations in the functional capacity of gut microbiota in patients with AUD when they stop drinking for 2-weeks. Sensitive microbial pathways to alcohol abstinence were identified in AUD patients. Further, we found the functional microbial responses to alcohol abstinence were different in AUD patients with different degree of hepatic steatosis. Our results provide insights into the link between functional alterations of the gut microbiota and steatosis associated with alcohol consumption.
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