期刊
FRONTIERS IN PHARMACOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2020.00730
关键词
PPAR alpha; PPAR gamma; PPAR beta/delta; inflammatory bowel diseases; ulcerative colitis; Crohn's disease
资金
- Proyecto de Investigacion en Salud - Consejeria de Salud y Familias, Junta de Andalucia [PI-0139-2018]
- Instituto de Salud Carlos III (ISCIII) [DTS19/00125]
- European Social Fund Investing in your future
- ISCIII [CD16/00067, CP14/00173, CPII17/00024]
- Servicio Andaluz de Salud, Junta de Andalucia [C1-0049-2019]
- European Regional Development Fund (ERDF) A way to make Europe
- Proyecto de Investigacion en Salud - Instituto de Salud Carlos III (ISCIII) [PI19/01577]
The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that promote ligand-dependent transcription of target genes that regulate energy production, lipid metabolism, and inflammation. The PPAR superfamily comprises three subtypes, PPAR alpha, PPAR gamma, and PPAR beta/delta, with differential tissue distributions. In addition to their different roles in the regulation of energy balance and carbohydrate and lipid metabolism, an emerging function of PPARs includes normal homeostasis of intestinal tissue. PPAR alpha activation represses NF-kappa B signaling, which decreases the inflammatory cytokine production by different cell types, while PPAR gamma ligands can inhibit activation of macrophages and the production of inflammatory cytokines, such as tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, and Il-1 beta. In this regard, the anti-inflammatory responses induced by PPAR activation might restore physiopathological imbalances associated with inflammatory bowel diseases (IBD). Thus, PPARs and their ligands have important therapeutic potential. This review briefly discusses the roles of PPARs in the physiopathology and therapies of the most important IBDs, ulcerative colitis (UC), and Crohn's disease (CD), as well some new experimental compounds with PPAR activity as promising drugs for IBD treatment.
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