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Feng Zhu et al.
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Pilar Rivero-Rios et al.
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Meiyu Zhang et al.
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Marie Therese Fuzzati-Armentero et al.
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Susanne Fonseca Santos et al.
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Bojan Shutinoski et al.
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Seona Park et al.
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Rebecca L. Wallings et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
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Tahmina Nasrin Poly et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2019)
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Daniel C. Berwick et al.
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Single Inflammatory Trigger Leads to Neuroinflammation in LRRK2 Rodent Model without Degeneration of Dopaminergic Neurons
Anna Schildt et al.
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Neurite Collapse and Altered ER Ca2+ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
Joanna A. Korecka et al.
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Federica Albanese et al.
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Zhiyong Liu et al.
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Jiayan Chen et al.
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Tetta Fujimoto et al.
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Elena Kozina et al.
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Anetta Hartlova et al.
EMBO JOURNAL (2018)
Blood-brain barrier breakdown in Alzheimer disease and other neurodegenerative disorders
Melanie D. Sweeney et al.
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Tetsuya Takagawa et al.
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Ken Y. Hui et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
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Inga Peter et al.
JAMA NEUROLOGY (2018)
The Frail Brain Blood Barrier in Neurodegenerative Diseases: Role of Early Disruption of Endothelial Cell-to-Cell Connections
Jessica Maiuolo et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
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Li Ren et al.
MEDICINE (2018)
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Isabella Russo et al.
JOURNAL OF NEUROINFLAMMATION (2018)
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Bryan A. Killinger et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
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Nicolas Dzamko et al.
MOVEMENT DISORDERS (2017)
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Weiwei Liu et al.
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Jeongho Park et al.
JOURNAL OF LEUKOCYTE BIOLOGY (2017)
Penetrance Estimate of LRRK2 p.G2019S Mutation in Individuals of Non-Ashkenazi Jewish Ancestry
Annie J. Lee et al.
MOVEMENT DISORDERS (2017)
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Katrina M. de lange et al.
NATURE GENETICS (2017)
High-dimensional, single-cell characterization of the brain's immune compartment
Ben Korin et al.
NATURE NEUROSCIENCE (2017)
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Mingming Zhang et al.
NEUROSCIENCE (2017)
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Roisin M. McManus et al.
ALZHEIMERS RESEARCH & THERAPY (2017)
Rab GTPases in Immunity and Inflammation
Akriti Prashar et al.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2017)
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D. A. Cook et al.
NPJ PARKINSONS DISEASE (2017)
LRRK2 modulates microglial activity through regulation of chemokine (C-X3-C) receptor 1-mediated signalling pathways
Bo Ma et al.
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Chih-Hao Shen et al.
MEDICINE (2016)
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Nicolas Dzamko et al.
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Martin Steger et al.
ELIFE (2016)
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Corinna Bliederhaeuser et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
Cellular processes associated with LRRK2 function and dysfunction
Rebecca Wallings et al.
FEBS JOURNAL (2015)
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Joao P. L. Daher et al.
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Isabella Russo et al.
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Jenna M. Puccini et al.
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Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations
Jimmy Z. Liu et al.
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Commensal bacteria direct selective cargo sorting to promote symbiosis
Qin Zhang et al.
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Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium
Karen Marder et al.
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Agata Mulak et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2015)
LRRK2 G2019S mutation attenuates microglial motility by inhibiting focal adhesion kinase
Insup Choi et al.
NATURE COMMUNICATIONS (2015)
Changes in matrix metalloprotease activity and progranulin levels may contribute to the pathophysiological function of mutant leucine-rich repeat kinase 2
Mareike Caesar et al.
GLIA (2014)
Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy
Jason Schapansky et al.
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Interferon- induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages
Martin Kuss et al.
JOURNAL OF NEUROCHEMISTRY (2014)
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Oleg Butovsky et al.
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Joao P. L. Daher et al.
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Association of Parkinson Disease with Structural and Regulatory Variants in the HLA Region
William T. Wissemann et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Differential distribution and activation of microglia in the brain of male C57BL/6J mice
Ting-Ting Yang et al.
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A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinsons disease
Peter Holmans et al.
HUMAN MOLECULAR GENETICS (2013)
Microglia and macrophages of the central nervous system: the contribution of microglia priming and systemic inflammation to chronic neurodegeneration
V. Hugh Perry et al.
SEMINARS IN IMMUNOPATHOLOGY (2013)
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Vera Dias et al.
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Peter Teismann
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Joao Paulo L. Daher et al.
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Mark S. Moehle et al.
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Wim Mandemakers et al.
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F. Gillardon et al.
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Beomsue Kim et al.
PLOS ONE (2012)
The IkappaB Kinase Family Phosphorylates the Parkinson's Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling
Nicolas Dzamko et al.
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Parkinson's disease or Parkinson symptoms following seasonal influenza
Stephen Toovey et al.
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Mansoureh Hakimi et al.
JOURNAL OF NEURAL TRANSMISSION (2011)
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Michael A. Nalls et al.
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Zhihua Liu et al.
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S. Sharma et al.
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Jonathan Thevenet et al.
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Jane A. Driver et al.
BMJ-BRITISH MEDICAL JOURNAL (2011)
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Karen Nuytemans et al.
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Agnes Gardet et al.
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Misuzu Saiki et al.
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Taye H. Hamza et al.
NATURE GENETICS (2010)
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Malu G. Tansey et al.
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Anti-inflammatory drugs and risk of Parkinson disease A meta-analysis
Joshua J. Gagne et al.
NEUROLOGY (2010)
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Vanessa Brochard et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
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Christoph D. Schmid et al.
JOURNAL OF NEUROCHEMISTRY (2009)
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Xian Lin et al.
NEURON (2009)
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M. Westerlund et al.
NEUROSCIENCE (2008)
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Shinji Higashi et al.
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S. Goldwurm et al.
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Shinji Higashi et al.
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Saskia Biskup et al.
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Judith Miklossy et al.
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LRRK2 expression linked to dopamine-innervated areas
D Galter et al.
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H Melrose et al.
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HL Chen et al.
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CF Orr et al.
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P Teismann et al.
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