期刊
EMERGING MICROBES & INFECTIONS
卷 9, 期 1, 页码 1170-1173出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/22221751.2020.1772676
关键词
Novel coronavirus; alkaloid; broad-spectrum antiviral; 2019-nCoV; SARS-CoV-2
资金
- National Key Research and Development Program of China [2018YFA0507201]
The emerging SARS-CoV-2 infection associated with the outbreak of viral pneumonia in China is ongoing worldwide. There are no approved antiviral therapies to treat this viral disease. Here we examined the antiviral abilities of three broad-spectrum antiviral compounds gemcitabine, lycorine and oxysophoridine against SARS-CoV-2 in cell culture. We found that all three tested compounds inhibited viral replication in Vero-E6 cells at noncytotoxic concentrations. The antiviral effect of gemcitabine was suppressed efficiently by the cytidine nucleosides. Additionally, combination of gemcitabine with oxysophoridine had an additive antiviral effect against SARS-CoV-2. Our results demonstrate that broad-spectrum antiviral compounds may have a priority for the screening of antiviral compounds against newly emerging viruses to control viral infection.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据