New Trends in Enantioselective Cross-Dehydrogenative Coupling

The development of cross-dehydrogenative coupling in recent years has simplified the synthesis of many materials, as a result of facile C-H activation, which, together with its greater atom economy and environmental friendliness, has made an impact on modern organic chemistry. Indeed, many C-C and C-X (X = N, O, P, S, B, or Si) coupling reactions can now be performed directly between two C-H bonds or a C-H and an X-H bond, simply by adding catalytic amounts of a metal salt to a mixture of the two and an oxidant to accept the two hydrogen atoms released. Chiral organocatalysts or chiral ligands have been joined to promote enantioselective processes, resulting in the development of efficient reaction cascades that provide products in high yields and high levels of asymmetric induction through cooperative catalysis. In recent years, photochemical oxidation and electrochemistry have widened even more the scope of cross-dehydrogenative coupling (CDC). In this review, we summarized the recent literature in this subject, hoping that it will inspire many new synthetic strategies.