期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 128, 期 4, 页码 1058-1065出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2020.1749085
关键词
Breast cancer; miRNAs; circulating molecular marker; MMP2; diagnosis
资金
- Science Technology Development Fund (STDF) through Basic and Applied Research Support Grant Project (BARG), Egypt [15089]
- Science Technology Development Fund (STDF) through Capacity Building Grant Project (CBG) [4940]
Expression levels of miR-29a and miR-335 have significant potential as biomarkers in breast cancer diagnosis.
Background: Circulating miRNAs are novel biomarkers, authors aimed to investigate the expression level of miR-29a and miR-335 and their relevance to CEA, CA15.3, and matrix metalloproteinase-2 (MMP2). Materials and methods: Breast cancer (BC) patients (n = 44), benign breast lesion patients (n = 25), and healthy individuals (n = 19) were enrolled for detection of miRNA expression levels, MMP2 and biochemical markers using quantitative polymerase chain reaction (PCR) and ELISA, respectively. Results: Expression of miR-29a and miR-335 were significantly decreased in breast patients as compared to healthy individuals, while biochemical markers were high in BC patients as compared to the other two groups. The diagnostic efficacy for miR-29a, miR-335, and MMP2 were superior to both CEA and CA 15.3 for early detection of BC patients. Conclusions: Detection of the miR-29a and miR335 expression levels in serum samples are significant promising biomarkers for BC diagnosis.
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