期刊
MICROMACHINES
卷 11, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/mi11040381
关键词
organ-on-a-chip; drug toxicity; drug metabolism
类别
资金
- National Natural Science Foundation of China (NNSFC) [21675017]
- National Key Research and Development Program of China [2017YFC1702001]
- Shenzhen Fundamental Research and Discipline Layout project [JCYJ2018050815247476]
- China Postdoctoral Science Foundation [21675017]
- State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products [KF20190108]
- Sanming Project of Medicine in Shenzhen [SZSM201612049]
Organ-on-a-chip academic research is in its blossom. Drug toxicity evaluation is a promising area in which organ-on-a-chip technology can apply. A unique advantage of organ-on-a-chip is the ability to integrate drug metabolism and drug toxic processes in a single device, which facilitates evaluation of toxicity of drug metabolites. Human organ-on-a-chip has been fabricated and used to assess drug toxicity with data correlation with the clinical trial. In this review, we introduced the microfluidic chip models of liver, kidney, heart, nerve, and other organs and multiple organs, highlighting the application of these models in drug toxicity detection. Some biomarkers of toxic injury that have been used in organ chip platforms or have potential for use on organ chip platforms are summarized. Finally, we discussed the goals and future directions for drug toxicity evaluation based on organ-on-a-chip technology.
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