期刊
JOURNAL OF THE AMERICAN HEART ASSOCIATION
卷 9, 期 11, 页码 -出版社
WILEY
DOI: 10.1161/JAHA.120.016349
关键词
epigenetics; histone deacetylase inhibitors; myocardial infarction; stroke; cardiac arrest
资金
- National Institutes of Health [K12HL133304-01]
Ischemia/reperfusion injury is a complex molecular cascade that causes deleterious cellular damage and organ dysfunction. Stroke, sudden cardiac arrest, and acute myocardial infarction are the most common causes of ischemia/reperfusion injury without effective pharmacologic therapies. Existing preclinical evidence suggests that histone deacetylase inhibitors may be an efficacious, affordable, and clinically feasible therapy that can improve neurologic and cardiac outcomes following ischemia/reperfusion injury. In this review, we discuss the pathophysiology and epigenetic modulations of ischemia/reperfusion injury and focus on the neuroprotective and cardioprotective effects of histone deacetylase inhibitors. We also summarize the protective effects of histone deacetylase inhibitors for other vital organs and highlight the key research priorities for their successful translation to the bedside.
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