期刊
INFECTIOUS AGENTS AND CANCER
卷 15, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13027-020-00302-x
关键词
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资金
- H2020 Transcan2-HEPAMUT project [643638]
- Italian Ministry of Health through Institutional Ricerca Corrente
- POR FESR 2014/2020 Campania OncoTerapie
- H2020 Societal Challenges Programme [643638] Funding Source: H2020 Societal Challenges Programme
The new human coronavirus named SARS-CoV-2 is a positive-sense RNA virus for which no specific drugs are currently available. A knowledge-based analysis strongly suggests a possible repositioning of the anti-HCV direct antiviral agent (DAA) Sofosbuvir as treatment for SARS-CoV-2. Indeed, the RNA-dependent RNA-polymerases (RdRp) of the two viruses show high sequence and structural homology, supporting the likelihood of binding the Sofosbuvir molecule with similar efficiency. Such a repositioning would allow the containment of the SARS-CoV-2 pandemic and limit the progression of disease to potentially deadly COVID19.
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