期刊
FRONTIERS IN MICROBIOLOGY
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2020.00739
关键词
Vibrio cholerae; enteropathogen; respiration; nitrate; fumarate; TMAO; fermentation; fitness
类别
资金
- Kempe Foundation
- Swedish Research Council
- Laboratory for Molecular Infection Medicine Sweden (MIMS)
- UCMR
- MIMS
- Knut and Alice Wallenberg Foundation (KAW)
Bacteria can colonize virtually any environment on Earth due to their remarkable capacity to detect and respond quickly and adequately to environmental stressors.Vibrio choleraeis a cosmopolitan bacterium that inhabits a vast range of environments. TheV. choleraelife cycle comprises diverse environmental and infective stages. The bacterium is found in aquatic ecosystems both under free-living conditions or associated with a wide range of aquatic organisms, and some strains are also capable of causing epidemics in humans. In order to adapt between environments,V. choleraepossesses a versatile metabolism characterized by the rapid cross-regulation of energy-producing pathways. Low oxygen concentration is a key environmental factor that governsV. choleraephysiology. This article reviews the metabolic plasticity that enablesV. choleraeto thrive on low oxygen concentrations and its role in environmental and host adaptation.
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