期刊
CHEMOSPHERE
卷 154, 期 -, 页码 546-551出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2016.04.011
关键词
Caenorhabditis elegans; Bisphenol A; Long-term exposure; Ecotoxicological evaluation; Environmental risks
资金
- NIH Office of Research Infrastructure Programs [P40 OD010440]
- National Environmental Protection Public Welfare Science and Technology Research Program of China [201309047]
- National Natural Science Foundation of China [51578240, 51378208, 41273109]
- Program for New Century Excellent Talents in University [NCET-13-0797]
- Innovation Program of Shanghai Municipal Education Commission [14ZZ059]
- Fok Ying Tung Education Foundation [141077]
- Fundamental Research Funds for the Central Universities [222201313008, 222201516015]
- Innovation Program of Shanghai municipal of Science and Technology Commission [15DZ1205804]
To investigate biological effects of bisphenol A (BPA) over the long term, the model animal Caenorhabditis elegans was used to conduct the chronic exposure. C. elegans were exposed to BPA (0.0001-10 mu M) from L4 larvae to day-10 adult in the present chronic toxicity assay system. Multiple endpoints at the physiological (growth, locomotion behaviors and lifespan), biochemical (lipofuscin accumulation), molecular (stress-related genes expressions), and population (population size) levels were examined. At the physiological level, BPA exposure induced significant negative effects on the indicators. Among the endpoints, head thrash was most sensitive and the detection limit was 0.001 mu M. At the biochemical level, BPA exposure induced no significant effects on lipofuscin accumulation. At the molecular level, BPA induced strong stress responses in vivo. At the population level, the population size was significantly decreased in the treatment groups from 0.1 to 10 mu M. Compared to the previous short-term toxicity evaluation, long-term exposure to BPA induced a more obvious response at the same concentration, and the phenomenon might be due to cumulative toxic effects. By the Pearson correlation analyses, cep-1 was speculated to act as an important role in BPA-induced chronic toxicity on C. elegans. (C) 2016 Elsevier Ltd. All rights reserved.
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