期刊
ELIFE
卷 9, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.53232
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资金
- Wellcome [203730/Z/16/Z, 203139/Z/16/Z, SBF003\1116, 101092/Z/13/Z]
- National Institute for Health Research Oxford Biomedical Research Centre
- Biotechnology and Biological Sciences Research Council [BB/N019814/1, BB/H016902/1]
- Dutch National Science Foundation [452-13-015]
- Academy of Medical Sciences
- British Heart Foundation
- UK Government Department of Business, Energy and Industrial Strategy
- European Commission [750026]
- Medical Research Council [MR/L009013/1]
- National Institute for Health Research
- National Institutes of Health [R01MH118534, P50MH100029, R01MH118285]
- Wellcome Trust [203730/Z/16/Z, 101092/Z/13/Z] Funding Source: Wellcome Trust
- BBSRC [BB/H016902/1, BB/N019814/1] Funding Source: UKRI
- MRC [MR/L009013/1] Funding Source: UKRI
- Marie Curie Actions (MSCA) [750026] Funding Source: Marie Curie Actions (MSCA)
Evolutionary adaptations of temporo-parietal cortex are considered to be a critical specialization of the human brain. Cortical adaptations, however, can affect different aspects of brain architecture, including local expansion of the cortical sheet or changes in connectivity between cortical areas. We distinguish different types of changes in brain architecture using a computational neuroanatomy approach. We investigate the extent to which between-species alignment, based on cortical myelin, can predict changes in connectivity patterns across macaque, chimpanzee, and human. We show that expansion and relocation of brain areas can predict terminations of several white matter tracts in temporo-parietal cortex, including the middle and superior longitudinal fasciculus, but not the arcuate fasciculus. This demonstrates that the arcuate fasciculus underwent additional evolutionary modifications affecting the temporal lobe connectivity pattern. This approach can flexibly be extended to include other features of cortical organization and other species, allowing direct tests of comparative hypotheses of brain organization.
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