期刊
ELIFE
卷 9, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.53268
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资金
- European Commission [Flag-Era JTC PCI2018-092891]
- Ministerio de Economia y Competitividad Juan de la Cierva Fellowship [IJCI-2014-21937]
- European Regional Development Fund [SAF2013-46717-R, SAF2010-15730]
- Ministerio de Economia y Competitividad [SAF2013-46717-R, SAF2010-15730, BES-2011-049131, PSI2016-75688-P]
- European Regional Development Fund
- Horizon 2020 Framework Programme [785907 HBP SGA1, 785907 HBP SGA2]
- Catalan Research Group Support [2017 SGR 1545]
Previous research showed that spontaneous neuronal activity presents sloppiness: the collective behavior is strongly determined by a small number of parameter combinations, defined as 'stiff' dimensions, while it is insensitive to many others ('sloppy' dimensions). Here, we analyzed neural population activity from the auditory cortex of anesthetized rats while the brain spontaneously transited through different synchronized and desynchronized states and intermittently received sensory inputs. We showed that cortical state transitions were determined by changes in stiff parameters associated with the activity of a core of neurons with low responses to stimuli and high centrality within the observed network. In contrast, stimulus-evoked responses evolved along sloppy dimensions associated with the activity of neurons with low centrality and displaying large ongoing and stimulus-evoked fluctuations without affecting the integrity of the network. Our results shed light on the interplay among stability, flexibility, and responsiveness of neuronal collective dynamics during intrinsic and induced activity.
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