期刊
CURRENT DRUG DELIVERY
卷 17, 期 6, 页码 470-482出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567201817666200512104833
关键词
Drug nanocrystals; manufacturing methods; physical and chemical stability; regulatory guideline; marketed products; bioavailability
Drug nanocrystals offer an attractive approach for improving the solubility and dissolution rate of poorly soluble drugs which accounts for nearly 40 % newly discovered drug molecules. Both methods for manufacturing drug nanocrystals have high industrial acceptability for being simple and easy to scale which is evident from the number of approved products available in the market. Ability to modify multiple aspects of dosage form like bioavailability, release pattern and dosage form requirement along with flexibility in choosing final dosage form starting from the tablet, capsule, suspension to parenteral one, have made nanocrystal technology one of the very promising and adaptable technology for dosage form design.
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