期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 9, 期 5, 页码 793-800出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.202000110
关键词
Regioselectivity; Dicarbofunctionalization; DFT calculation; Nickel catalysis; Mechanistic study
资金
- National Natural Science Foundation of China [21973068]
- project of scientific and technologic infrastructure of Suzhou [SZS201708]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Herein, the origins of organohalide-dependent regioselectivities for Ni-catalyzed dicarbofunctionalization of allyl moiety of N-allyl-2-aminopyrimidine were explored by computational studies. When aryl iodides are used for the dicarbofunctionalization, the detailed reaction mechanistic pathway follows the sequential oxidative addition (OA), migratory insertion (MI), beta-H elimination, H-migration, transmetalation, and reductive elimination (RE) to afford the 1,3-dicarbofunctionalization products. Due to the presence of chelation of the pyrimidinyl moiety of substrate with Ni, the competitive beta-H elimination leading to the product of Heck reaction is less favourable and thus the regioselective beta-H elimination occurs. The formation of thermodynamically more stable intermediate is the driving force for the subsequent H-migration. When alkenyl bromides are used, alternative regioselectivity to give 1,2-dicarbofunctionalization products is obtained and the proposed mechanistic pathway proceeds sequentially via OA, MI, transmetalation, and RE. The main reason accounting for the different regioselectivity between aryl iodides and alkenyl bromides involved in dicarbofunctionalization is revealed. In addition, the reversed 2,1-regioselectivity achieved by using alkynyl halides in the Ni-catalyzed dicarbofunctionalization is via sequential steps of OA, transmetalation, MI, and RE. The mechanistic difference that the migratory insertion step is unlikely to occur after OA, which is in contrast to the other two mechanistic pathways, is rationalized.
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