Auto-Oxidative Povarov/Aromatization Tandem Reaction of Glycine Derivatives with Enamides: Acylamino as both Activating and Leaving Group

The auto-oxidative Povarov/aromatization tandem reaction of N-aryl glycine derivatives with enamides yields a series of complex quinoline derivatives in good yields. The reactions are performed using only catalytic amount of Bronsted acid and O-2. The acylamino group is used as both activating and leaving group to improve the reaction efficiency in this transformation.