期刊
CHEMOSPHERE
卷 160, 期 -, 页码 95-103出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2016.06.068
关键词
Bivalves; Oxidative stress; Pharmaceuticals; Long-term exposure; Environmentally relevant concentrations
资金
- National Funds through the Portuguese Science Foundation (FCT) - FSE [SFRH/BPD/92258/2013, SFRH/BPD/78645/2011, SFRH/BD/110218/2015]
- Programa Operational Capital Humana (POCH) e da Uniao Europeia
- CESAM [UID/AMB/50017]
- FCT/MEC through national funds
- FEDER
- Fundação para a Ciência e a Tecnologia [SFRH/BD/110218/2015] Funding Source: FCT
Caffeine is known to be one of the most consumed psychoactive drugs. For this reason, caffeine is continuously released into the environment with potential impacts on inhabiting organisms. The current study evaluated the biochemical alterations induced in the clam species Ruditapes philippinarum after exposure for 28 days to caffeine (0.5, 3.0 and 18.0 mu g/L). The results obtained showed that, with the increasing caffeine concentrations, an increase in clams defense mechanisms (such as antioxidant and biotransformation enzymes activity) was induced which was accompanied by an increase in protein content. Nevertheless, although an increase on defense mechanisms was observed, clams were not able to prevent cells from lipid peroxidation that increased with the increase of caffeine concentration. Furthermore, with the increase of exposure concentrations, clams increased their metabolic activity (measured by electron transport activity), reducing their energy reserves (glycogen content), to fight against oxidative stress. Overall, the present study demonstrated that caffeine may impact bivalves, even at environmentally relevant concentrations, inducing oxidative stress in organisms. The present study is an important contribution to address knowledge gaps regarding the impacts of long-term exposures to pharmaceuticals since most of the studies assessed the effects after acute exposures, most of them up to 96 h. (C) 2016 Published by Elsevier Ltd.
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