期刊
BLOOD
卷 125, 期 11, 页码 1703-1707出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2014-12-567834
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资金
- National Institutes of Health, National Heart, Lung, and Blood Institute [K08HL107756]
- National Cancer Institute [P01CA142106]
Recent studies have compelled further interest in the potential pathological role of B cells in chronic graft-versus-host disease (cGVHD). In patients with cGVHD, B cells are activated and primed for survival viaB-cell activating factor and B-cell receptor-associated pathways. Understanding the signaling pathways that drive immune pathology in cGVHD will facilitate the development of new strategies to selectively target aberrantly activated B cells and restore normal B-cell homeostasis after allogeneic stem cell transplantation.
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