4.7 Article

Fatty liver disease induced by perfluorooctane sulfonate: Novel insight from transcriptome analysis

期刊

CHEMOSPHERE
卷 159, 期 -, 页码 166-177

出版社

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.chemosphere.2016.05.060

关键词

Hepatotoxicity; Perfluorooctane sulfonate; Transcriptome; Zebrafish; Environmental pollutant

资金

  1. Health and Medical Research Fund, Hong Kong [12132881]
  2. Seed Funding Programme for Basic Research
  3. University of Hong Kong, Hong Kong [201308159001]
  4. Faculty Research Fund from Hong Kong Baptist University [FRG1/14-15/075, FRG2/14-15/005]
  5. Lo Kwee-Seong Biomedical Research Fund
  6. Lee Hysan Foundation

向作者/读者索取更多资源

Perfluorooctane sulfonate (PFOS), a hepato-toxicant and potential non-genotoxic carcinogen, was widely used in industrial and commercial products. Recent studies have revealed the ubiquitous occurrence of PFOS in the environment and in humans worldwide. The widespread contamination of PFOS in human serum raised concerns about its long-term toxic effects and its potential risks to human health. Using fatty liver mutant foie gras (fgr(-/-))/transport protein particle complex 11 (trappc11(-/-)) and PFOS-exposed wild-type zebrafish embryos as the study model, together with RNA sequencing and comparative transcriptomic analysis, we identified 499 and 1414 differential expressed genes (DEGs) in PFOS-exposed wild-type and trappc11 mutant zebrafish, respectively. Also, the gene ontology analysis on common deregulated genes was found to be associated with different metabolic processes such as the carbohydrate metabolic process, glycerol ether metabolic process, mannose biosynthetic process, de novo' (Guanosine diphosphate) GDP-L-fucose biosynthetic process, GDP-mannose metabolic process and galactose metabolic process. Ingenuity Pathway Analysis further highlighted that these deregulated gene clusters are closely related to hepatitis, inflammation, fibrosis and cirrhosis of liver cells, suggesting that PFOS can cause liver pathogenesis and non-alcoholic fatty liver disease in zebrafish. The transcriptomic alterations revealed may serve as biomarkers for the hepatotoxic effect of PFOS. (C) 2016 Elsevier Ltd. All rights reserved.

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