期刊
PROTEIN & CELL
卷 11, 期 6, 页码 401-416出版社
SPRINGER
DOI: 10.1007/s13238-020-00722-w
关键词
epigenetics; metabolism; non-enzymatic modification; chromatin; human disease
类别
资金
- CCSG core grant [P30 CA008748]
- National Institutes of Health [SPORE P50-CA192937]
- Tri-institutional Therapeutic Discovery Institute
- Commonwealth Foundation for Cancer Research
- Center for Experimental Therapeutics at MSKCC
- Pershing Square Sohn Cancer Research Alliance
- Cycle for Survival
- Parker Institute for Cancer Immunotherapy
- Anna Fuller Cancer Research Foundation
- [R21 DA044767]
Epigenetic modifications, including those on DNA and histones, have been shown to regulate cellular metabolism by controlling expression of enzymes involved in the corresponding metabolic pathways. In turn, metabolic flux influences epigenetic regulation by affecting the biosynthetic balance of enzyme cofactors or donors for certain chromatin modifications. Recently, non-enzymatic covalent modifications (NECMs) by chemically reactive metabolites have been reported to manipulate chromatin architecture and gene transcription through multiple mechanisms. Here, we summarize these recent advances in the identification and characterization of NECMs on nucleic acids, histones, and transcription factors, providing an additional mechanistic link between metabolism and epigenetics.
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