期刊
出版社
MDPI
DOI: 10.3390/ijerph17072326
关键词
food; diet; lifestyle; classical and emerging risk factors; atherosclerosis; arterial hypertension; diabetes; coronary artery disease; plant-food bioactive compounds; cardio-protective pharmacotherapy
资金
- Portuguese Foundation for Science and Technology (FCT-Portugal) [UID/BIM/04293/2013]
- NORTE2020 - Programa Operacional Regional do Norte [NORTE-01-0145-FEDER-000012]
- FCT/MCTES (PIDDAC) [UID/EQU/00511/2019]
Heart and blood vessels disorders comprise one of the main causes of death worldwide. Pharmacologically active natural compounds have been used as a complementary therapy in cardiovascular disease around the world in a traditional way. Dietary, natural bioactive compounds, as well as healthy lifestyles, are considered to prevent coronary artery diseases. Pre-clinical and clinical studies reported that consumption of plant-food bioactive derivatives including polyphenolic compounds, peptides, oligosaccharides, vitamins, unsaturated fatty acids possess protective effects on cardiovascular diseases. This review aims to summarize the cardiovascular risk factors, pre-clinical studies and clinical trials related to cardioprotective properties of the plant-food-derived bioactive compounds. Molecular mechanisms by the natural bioactive compounds exert their cardiovascular protective properties have also been highlighted.
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