期刊
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
卷 28, 期 3, 页码 294-300出版社
OXFORD UNIV PRESS
DOI: 10.1177/2047487320915338
关键词
Cardiovascular health metrics; sudden cardiac death; all-cause mortality; risk factors; men
资金
- Finnish Foundation for Cardiovascular Research, Helsinki, Finland
- NIHR Biomedical Research Centre at University Hospitals Bristol NHS Foundation Trust and the University of Bristol
The study found that ideal cardiovascular health metrics were linearly associated with decreased risks of sudden cardiac death and all-cause mortality among middle-aged men in Finland. As the number of cardiovascular health metrics increased, the risks of sudden cardiac death and all-cause mortality continued to decrease. Men with ideal cardiovascular health scores had significantly lower risks of sudden cardiac death and all-cause mortality compared to those with poor cardiovascular health scores.
Background Strong associations have been demonstrated between the American Heart Association's cardiovascular health (CVH) metrics and various cardiovascular outcomes, but the association with sudden cardiac death (SCD) is uncertain. We examined the associations between these CVH metrics and the risks of SCD and all-cause mortality among men in Finland. Methods and results We used the prospective population-based Kuopio Ischaemic Heart Disease cohort study, which consists of men between 42 and 60 years of age at baseline. CVH metrics were computed for 2577 men with CVH scores at baseline ranging from 0 to 7, categorized into CVH scores of 0-2 (poor), 3-4 (intermediate) and 5-7 (ideal). Multivariate Cox regression models were used to estimate the hazards ratios (HRs) and 95% confidence intervals (CIs) of ideal CVH metrics for SCD and all-cause mortality. During a median follow-up period of 25.8 years, 280 SCDs and 1289 all-cause mortality events were recorded. The risks of SCD and all-cause mortality decreased continuously with increasing number of CVH metrics across the range 2-7 (p value for non-linearity for all <0.05). In multivariable analyses, men with an ideal CVH score had an 85% reduced risk of SCD compared with men with a poor CVH score (HR 0.15; 95% CI 0.05-0.48; p = 0.001). For all-cause mortality, there was a 67% lower risk among men with an ideal CVH score compared with those with a poor CVH score (HR 0.33; 95% CI 0.23-0.49; p <0.001). Conclusions Ideal CVH metrics were strongly and linearly associated with decreased risks of SCD and all-cause mortality among middle-aged men in Finland.
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