期刊
CHEMPLUSCHEM
卷 85, 期 6, 页码 1156-1163出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cplu.202000360
关键词
antitumor agents; cytotoxicity; drug delivery; magnetic properties; nanoparticles
Development of therapeutic systems to treat glioblastoma, the most common and aggressive brain tumor, belongs to priority tasks in cancer research. We have synthesized colloidally stable magnetic nanoparticles (D-h=336 nm) coated with doxorubicin (Dox) conjugated copolymers ofN,N-dimethylacrylamide and eitherN-acryloylglycine methyl ester orN-acryloylmethyl 6-aminohexanoate. The terminal carboxyl groups of the copolymers were reacted with alendronate by carbodiimide formation. Methyl ester groups were then transferred to hydrazides for binding Dox by a hydrolytically labile hydrazone bond. The polymers were subsequently bound on the magnetic nanoparticles through bisphosphonate terminal groups. Finally, the anticancer effect of the Dox-conjugated particles was investigated using the U-87 glioblastoma cell line in terms of particle internalization and cell viability, which decreased to almost zero at a concentration of 100 mu g of particles per ml. These results confirmed that poly(N,N-dimethylacrylamide)-coated magnetic nanoparticles can serve as a solid support for Dox delivery to glioblastoma cells.
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