期刊
CELL REPORTS
卷 31, 期 2, 页码 -出版社
CELL PRESS
DOI: 10.1016/j.celrep.2020.03.079
关键词
-
类别
资金
- Netherlands Organisation for Scientific Research (NWO-ALW)
- Dutch Organization for Medical Sciences (ZonMW)
- ERCadv
- ERC-POC
- EU-LISTEN
- Medical NeuroDelta
- INTENSE (NWOLSH)
- NWO-ALW grant [ALW2PJ/12048]
- NWO VICI grant [ALW-Vici 016.150.673/865.14.002]
- ERCStG grant [680235]
- European Research Council (ERC) [680235] Funding Source: European Research Council (ERC)
The majority of excitatory postsynaptic currents in the brain are gated through AMPA-type glutamate receptors, the kinetics and trafficking of which can be modulated by auxiliary proteins. It remains to be elucidated whether and how auxiliary proteins can modulate synaptic function to contribute to procedural memory formation. In this study, we report that the AMPA-type glutamate receptor (AMPAR) auxiliary protein SHISA6 (CKAMP52) is expressed in cerebellar Purkinje cells, where it co-localizes with GIuA2-containing AMPARs. The absence of SHISA6 in Purkinje cells results in severe impairments in the adaptation of the vestibulo-ocular reflex and eyeblink conditioning. The physiological abnormalities include decreased presence of AMPARs in synaptosomes, impaired excitatory transmission, increased deactivation of AMPA receptors, and reduced induction of long-term potentiation at Purkinje cell synapses. Our data indicate that Purkinje cells require SHISA6-dependent modification of AMPAR function in order to facilitate cerebellar, procedural memory formation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据