期刊
CELL AND BIOSCIENCE
卷 10, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s13578-020-00401-7
关键词
Fanconi anemia; DNA repair; Tumorigenesis; Cancer intervention
资金
- National Institutes of Health [HL131013]
- DOD BCRP Breakthrough Grant [BC180657]
- University of Miami Sylvester Comprehensive Cancer Center Bridge Fund
- National Institutes of Health
- CDMRP [BC180657, 1102106] Funding Source: Federal RePORTER
Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and congenital abnormalities, FA is associated with chromosomal abnormality and genomic instability, and thus represents a genetic vulnerability for cancer predisposition. The cancer relevance of the FA pathway is further established with the pervasive occurrence of FA gene alterations in somatic cancers and observations of FA pathway activation-associated chemotherapy resistance. In this article we describe the role of the FA pathway in canonical interstrand crosslink (ICL) repair and possible contributions of FA gene alterations to cancer development. We also discuss the perspectives and potential of targeting the FA pathway for cancer intervention.
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