期刊
CANCER RESEARCH AND TREATMENT
卷 52, 期 4, 页码 1041-1049出版社
KOREAN CANCER ASSOCIATION
DOI: 10.4143/crt.2020.057
关键词
Anaplastic glioma; Extent of resection; Survival; Prognosis
类别
资金
- National Research Foundation of Korea (NRF) - Korean government [NRF-2014R1A1A2058058]
- Yonsei University College of Medicine [6-2018-0061]
Purpose The aim of this study is to evaluate the survival rate and prognostic factors of anaplastic gliomas according to the 2016 World Health Organization classification, including extent of resection (EOR) as measured by contrast-enhanced T1-weighted magnetic resonance imaging (MRI) and the T2-weighted MRI. Materials and Methods The records of 113 patients with anaplastic glioma who were newly diagnosed at our institute between 2000 and 2013 were retrospectively reviewed. There were 62 cases (54.9%) of anaplastic astrocytoma, isocitrate dehydrogenase (IDH) wild-type (AAw), 18 cases (16.0%) of anaplastic astrocytoma, IDH-mutant, and 33 cases (29.2%) of anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeletecl. Results The median overall survival (OS) was 48.4 months in the whole anaplastic glioma group and 21.5 months in Mw group. In multivariate analysis, age, preoperative Karnofsky Performance Scale score, O-6 -methylguanine-DNA methyltransferase (MGMT) methylation status, postoperative tumor volume, and EOR measured from the T2 MRI sequence were significant prognostic factors. The EOR cut-off point for OS measured in contrast-enhanced T1-weighted MRI and T2-weighted MRI were 99.96% and 85.64%, respectively. Conclusion We found that complete resection of the contrast-enhanced portion (99.96%) and more than 85.64% resection of the non-enhanced portion of the tumor have prognostic impacts on patient survival from anaplastic glioma.
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