期刊
CHEMMEDCHEM
卷 11, 期 15, 页码 1583-1586出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201600270
关键词
dendrimers; drug discovery; purity; stability; toxicity
资金
- Industrial Research Ltd. Capability Fund
- Ministry of Business, Innovation, and Employment Pre-Seed Accelerator Fund
Poly ethoxy ethyl glycinamide (PEE-G) dendrimers have been specifically designed and synthesized with the aim of providing a readily available dendrimer scaffold that can be used to make products that can meet the stringent requirements of pharmaceutical applications. The synthesis has been refined to produce dendrimers that are of high HPLC purity. The suitability of PEE-G dendrimers for their designed use has been verified by subsequent measurements to demonstrate that they are of high stability, high aqueous solubility, low cytotoxicity, low immunogenicity and with low invivo toxicity in an escalating-dose rat study. PEE-G dendrimers therefore provide a useful scaffold for researchers wanting to develop dendrimer-based drug candidates.
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