期刊
ADVANCES IN NUTRITION
卷 11, 期 4, 页码 989-1001出版社
OXFORD UNIV PRESS
DOI: 10.1093/advances/nmaa015
关键词
inactivity; orthopedic injury; muscle atropy; protein turnover; protein supplementation; rehabilitation
资金
- The Beef Checkoff
- USDA National Institute of Food and Agriculture, Hatch project [1016873]
Muscle atrophy and weakness occur as a consequence of disuse after musculoskeletal injury (MSI). The slow recovery and persistence of these deficits even after physical rehabilitation efforts indicate that interventions designed to attenuate muscle atrophy and protect muscle function are necessary to accelerate and optimize recovery from MSI. Evidence suggests that manipulating protein intake via dietary protein or free amino acid -based supplementation diminishes muscle atrophy and/or preserves muscle function in experimental models of disuse (i.e., immobilization and bed rest in healthy populations). However, this concept has rarely been considered in the context of disuse following MSI, which often occurs with some muscle activation during postinjury physical rehabilitation. Given that exercise sensitizes skeletal muscle to the anabolic effect of protein ingestion, early rehabilitation may act synergistically with dietary protein to protect muscle mass and function during postinjury disuse conditions. This narrative review explores mechanisms of skeletal muscle disuse atrophy and recent advances delineating the role of protein intake as a potential countermeasure. The possible synergistic effect of protein based interventions and postinjury rehabilitation in attenuating muscle atrophy and weakness following MSI is also considered.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据